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Int. J. Mol. Sci. 2013, 14(1), 244-254;

Nano Size Effects of TiO2 Nanotube Array on the Glioma Cells Behavior

Liaoning Provincial Universities Key Laboratory of Boron Resource Ecological Utilization Technology and Boron Materials, Northeastern University, No.11, Lane 3, Wenhua Road, Heping District, Shenyang 110819, China
Departments of Neurosurgery, The First Affiliated Hospital of China Medical University, 155 Nanjingbei Street, Heping District, Shenyang 110001, China
These authors contributed equally to this work.
Authors to whom correspondence should be addressed.
Received: 4 September 2012 / Revised: 26 November 2012 / Accepted: 11 December 2012 / Published: 21 December 2012
(This article belongs to the Section Materials Science)
Full-Text   |   PDF [559 KB, uploaded 19 June 2014]


In order to investigate the interplay between the cells and TiO2 nanotube array, and to explore the ability of cells to sense the size change in nano-environment, we reported on the behavior of glioma C6 cells on nanotube array coatings in terms of proliferation and apoptosis. The behavior of glioma C6 cells was obviously size-dependent on the coatings; the caliber with 15 nm diameter provided effective spacing to improve the cells proliferation and enhanced the cellular activities. C6 cells’ biological behaviors showed many similar tendencies to many phorocytes; the matching degree of geometry between nanotube and integrin defined that a spacing of 15 nm was optimal for inducing signals to nucleus, which results in achieving maximum activity of glioma cells. In addition, the immune behavior of cells was studied, a variety of inflammatory mediator’s gene expression levels were controlled by the nanoscale dimension, the expressions of IL-6 and IL-10 were higher on 30 nm than on 15 nm nanotube. View Full-Text
Keywords: nanotube; glioma cells; proliferation; inflammatory mediator’s gene; signal channel nanotube; glioma cells; proliferation; inflammatory mediator’s gene; signal channel
This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).

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Yang, H.; Qin, X.; Tian, A.; Zhang, D.; Xue, X.; Wu, A. Nano Size Effects of TiO2 Nanotube Array on the Glioma Cells Behavior. Int. J. Mol. Sci. 2013, 14, 244-254.

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