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Insulin Like Growth Factor-1 (IGF-1) Causes Overproduction of IL-8, an Angiogenic Cytokine and Stimulates Neovascularization in Isoproterenol-Induced Myocardial Infarction in Rats

1
Faculty of Medicine, Health and Molecular Sciences, James Cook University, Townsville 4811, Queensland, Australia
2
Division of Pathology, International Medical University, Kuala Lumpur 57000, Malaysia
3
Division of Human Biology, International Medical University, Kuala Lumpur 57000, Malaysia
*
Author to whom correspondence should be addressed.
Int. J. Mol. Sci. 2011, 12(12), 8562-8574; https://doi.org/10.3390/ijms12128562
Received: 20 August 2011 / Revised: 18 October 2011 / Accepted: 20 October 2011 / Published: 29 November 2011
(This article belongs to the Section Biochemistry)
Angiogenesis factors are produced in response to hypoxic or ischemic insult at the site of pathology, which will cause neovascularization. Insulin like growth factor-1 (IGF-1) exerts potent proliferative, angiogenic and anti-apoptotic effects in target tissues. The present study was aimed to evaluate the effects of IGF-1 on circulating level of angiogenic cytokine interleukin-8 (IL-8), in experimentally-induced myocardial ischemia in rats. Male Sprague-Dawley rats were divided into control, IGF-1 treated (2 µg/kg/day subcutaneously, for 5 and 10 days), isoproterenol (ISO) treated (85 mg/kg, subcutaneously for two days) and ISO with IGF-1 treated (for 5 and 10 days). Heart weight, serum IGF-1, IL-8 and cardiac marker enzymes (CK-MB and LDH) were recorded after 5 and 10 days of treatment. Histopathological analyses of the myocardium were also done. There was a significant increase in serum cardiac markers with ISO treatment indicating myocardial infarction in rats. IGF-1 level increased significantly in ISO treated groups and the level of IGF-1 was significantly higher after 10 days of treatment. IL-8 level increased significantly after ISO treatment after 5 and 10 days and IGF-1 concurrent treatment to ISO rats had significantly increased IL-8 levels. Histopathologically, myocyte necrosis and nuclear pyknosis were reduced significantly in IGF-1 treated group and there were numerous areas of capillary sprouting suggestive of neovascularization in the myocardium. Thus, IGF-1 protects the ischemic myocardium with increased production of circulating angiogenic cytokine, IL-8 and increased angiogenesis. View Full-Text
Keywords: IGF-1; isoproterenol; myocardial ischemia; angiogenesis; interleukin-8 IGF-1; isoproterenol; myocardial ischemia; angiogenesis; interleukin-8
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MDPI and ACS Style

Haleagrahara, N.; Chakravarthi, S.; Mathews, L. Insulin Like Growth Factor-1 (IGF-1) Causes Overproduction of IL-8, an Angiogenic Cytokine and Stimulates Neovascularization in Isoproterenol-Induced Myocardial Infarction in Rats. Int. J. Mol. Sci. 2011, 12, 8562-8574. https://doi.org/10.3390/ijms12128562

AMA Style

Haleagrahara N, Chakravarthi S, Mathews L. Insulin Like Growth Factor-1 (IGF-1) Causes Overproduction of IL-8, an Angiogenic Cytokine and Stimulates Neovascularization in Isoproterenol-Induced Myocardial Infarction in Rats. International Journal of Molecular Sciences. 2011; 12(12):8562-8574. https://doi.org/10.3390/ijms12128562

Chicago/Turabian Style

Haleagrahara, Nagaraja; Chakravarthi, Srikumar; Mathews, Lisa. 2011. "Insulin Like Growth Factor-1 (IGF-1) Causes Overproduction of IL-8, an Angiogenic Cytokine and Stimulates Neovascularization in Isoproterenol-Induced Myocardial Infarction in Rats" Int. J. Mol. Sci. 12, no. 12: 8562-8574. https://doi.org/10.3390/ijms12128562

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