Next Article in Journal
Evolutionary Divergence of Duplicate Copies of the Growth Hormone Gene in Suckers (Actinopterygii: Catostomidae)
Next Article in Special Issue
Quasi-Drugs Developed in Japan for the Prevention or Treatment of Hyperpigmentary Disorders
Previous Article in Journal
Stem Cell Tracking by Nanotechnologies
Previous Article in Special Issue
The Hunt for Natural Skin Whitening Agents
Open AccessReview

Tyrosinase-Expressing Neuronal Cell Line as in Vitro Model of Parkinson’s Disease

Department of Neurology Tohoku University School of Medicine, 1-1 Seiryomachi, Aobaku, Sendai, Miyagi 980-8574, Japan
Int. J. Mol. Sci. 2010, 11(3), 1082-1089; https://doi.org/10.3390/ijms11031082
Received: 18 January 2010 / Accepted: 3 March 2010 / Published: 12 March 2010
Oxidized metabolites of dopamine known as dopamine quinone derivatives are thought to play a pivotal role in the degeneration of nigrostriatal dopaminergic neurons in Parkinson’s disease. Although such quinone derivatives are usually produced via the autoxidation of catecholamines, tyrosinase, which is a key enzyme in melanin biosynthesis via the production of DOPA and subsequent molecules, can potentially accelerate the induction of catecholamine quinone derivatives by its oxidase activity. We have developed neuronal cell lines in which the expression of human tyrosinase was inducible. Overexpression of tyrosinase resulted in increased intracellular dopamine content in association with the formation of melanin pigments in neuronal somata, which eventually causes apoptotic cell death. This cellular model will provide a useful tool for detailed analyses of the neurotoxicity of oxidized catechol metabolites. View Full-Text
Keywords: tyrosinase; Parkinson’s disease; cellular model tyrosinase; Parkinson’s disease; cellular model
MDPI and ACS Style

Hasegawa, T. Tyrosinase-Expressing Neuronal Cell Line as in Vitro Model of Parkinson’s Disease. Int. J. Mol. Sci. 2010, 11, 1082-1089.

Show more citation formats Show less citations formats

Article Access Map by Country/Region

1
Only visits after 24 November 2015 are recorded.
Search more from Scilit
 
Search
Back to TopTop