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Molecules 2003, 8(6), 500-504; https://doi.org/10.3390/80600500

The Ring Transformation of 3-Methyl-5-nitropyrimidin-4(3H)-one

Department of Chemistry, Osaka Kyoiku University, Asahigaoka, Kashiwara, Osaka 582-8582, Japan
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Received: 13 May 2003 / Accepted: 15 May 2003 / Published: 30 June 2003
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Abstract

3-Methyl-5-nitropyrimidin-4(3H)-one readily reacts with carbonyl compounds to produce three kinds of ring transformations. The nitropyrimidinone behaves as the synthetic equivalent of activated diformylamine affording 3,5-difunctionalized 4-pyridones, 4,5-disubstituted pyrimidines and functionalized 4-aminopyridines. It also behaves like α-nitro-formylacetic acid to give 5,6-disubstituted 3-nitro-2-pyridones. View Full-Text
Keywords: Nitropyrimidinone; ring transformation; pyridone; pyrimidine; aminopyridine Nitropyrimidinone; ring transformation; pyridone; pyrimidine; aminopyridine
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Nishiwaki, N.; Tamura, M.; Hori, K.; Tohda, Y.; Ariga, M. The Ring Transformation of 3-Methyl-5-nitropyrimidin-4(3H)-one. Molecules 2003, 8, 500-504.

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