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This is an early access version, the complete PDF, HTML, and XML versions will be available soon.
Article

A Comprehensive Study of the Cobalt(II) Chelation Mechanism by an Iminodiacetate-Decorated Disaccharide Ligand

by
Cécile Barbot
1,
Laura Gouriou
1,
Mélanie Mignot
1,
Muriel Sebban
1,
Ping Zhang
2,
David Landy
3,
Chang-Chun Ling
2,* and
Géraldine Gouhier
1,*
1
Institut CARMeN UMR 6064, University Rouen Normandie, INSA Rouen Normandie, University Caen Normandie, ENSICAEN, CNRS, FR 3038, INSA Rouen, CNRS, IRCOF, 76821 Mont Saint Aignan, France
2
Department of Chemistry, University of Calgary, Calgary, AB T2N 1N4, Canada
3
UCEIV, UR4492 Université du Littoral Côte d’Opale, Department of Chemistry, 59140 Dunkerque, France
*
Authors to whom correspondence should be addressed.
Molecules 2025, 30(15), 3263; https://doi.org/10.3390/molecules30153263
Submission received: 1 July 2025 / Revised: 28 July 2025 / Accepted: 30 July 2025 / Published: 4 August 2025
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Abstract

We report an investigation on the cobalt(II) chelation mechanism by a modified α-maltoside ligand 9 decorated with two iminodiacetate (IDA) residues on C6,C6′ positions. Herein we uncovered the capacity of this biodegradable ligand to chelate cobalt(II), an ionic metal contaminant in the environment that is used, in particular, in lithium-ion batteries. The interactions between cobalt(II) and synthesized ligand 9 were systematically studied using different analytical methods such as 1H and 13C NMR, potentiometry, spectrophotometry, ITC, and ICP-AES. We observed a high affinity for the 1:1 complex, one cobalt(II) associated with two iminodiacetate groups, which is 10-fold higher than the 2:1 complex, where each of the two IDA groups interacts alone with a cobalt(II). Taking into account the log βCoLvalue obtained (≈12.3) with the stoichiometry 1:1, the strength of this complexation with cobalt(II) can be ranked as follows for the most common ligands: IDA < MIDA < NTA < 9 < EDTA < TTHA < DTPA. We further completed a preliminary remediation test with water contaminated with cobalt(II) and recovered cobalt(II) metal using Chelex® resin, which allowed a recycling of the synthetic ligand for future recovering experiments. The results shed light on the great potential of using this synthetic ligand as an effective and green remediation tool.
Keywords: cobalt(II) chelation; iminodiacetate ligand; α-maltoside; ITC; speciation diagram; binding constant cobalt(II) chelation; iminodiacetate ligand; α-maltoside; ITC; speciation diagram; binding constant
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MDPI and ACS Style

Barbot, C.; Gouriou, L.; Mignot, M.; Sebban, M.; Zhang, P.; Landy, D.; Ling, C.-C.; Gouhier, G. A Comprehensive Study of the Cobalt(II) Chelation Mechanism by an Iminodiacetate-Decorated Disaccharide Ligand. Molecules 2025, 30, 3263. https://doi.org/10.3390/molecules30153263

AMA Style

Barbot C, Gouriou L, Mignot M, Sebban M, Zhang P, Landy D, Ling C-C, Gouhier G. A Comprehensive Study of the Cobalt(II) Chelation Mechanism by an Iminodiacetate-Decorated Disaccharide Ligand. Molecules. 2025; 30(15):3263. https://doi.org/10.3390/molecules30153263

Chicago/Turabian Style

Barbot, Cécile, Laura Gouriou, Mélanie Mignot, Muriel Sebban, Ping Zhang, David Landy, Chang-Chun Ling, and Géraldine Gouhier. 2025. "A Comprehensive Study of the Cobalt(II) Chelation Mechanism by an Iminodiacetate-Decorated Disaccharide Ligand" Molecules 30, no. 15: 3263. https://doi.org/10.3390/molecules30153263

APA Style

Barbot, C., Gouriou, L., Mignot, M., Sebban, M., Zhang, P., Landy, D., Ling, C.-C., & Gouhier, G. (2025). A Comprehensive Study of the Cobalt(II) Chelation Mechanism by an Iminodiacetate-Decorated Disaccharide Ligand. Molecules, 30(15), 3263. https://doi.org/10.3390/molecules30153263

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