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Review

Recent Advances of N-2,2,2-Trifluoroethylisatin Ketimines in Organic Synthesis

by
Yuting Liu
1,†,
Lijie Wang
1,†,
Donglai Ma
1,2,3,* and
Yongxing Song
1,2,3,*
1
College of Pharmacy, Hebei University of Chinese Medicine, Shijiazhuang 050200, China
2
Hebei Technology Innovation Center of TCM Formula Preparations, Hebei University of Chinese Medicine, Shijiazhuang 050200, China
3
Hebei Technological Innovation Center of Chiral Medicine, Hebei Chemical & Pharmaceutical College, Shijiazhuang 050026, China
*
Authors to whom correspondence should be addressed.
†
These authors contributed equally to this work.
Molecules 2023, 28(7), 2990; https://doi.org/10.3390/molecules28072990
Submission received: 24 February 2023 / Revised: 23 March 2023 / Accepted: 26 March 2023 / Published: 27 March 2023
(This article belongs to the Special Issue Recent Advances of Catalytic Asymmetric Synthesis)
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Abstract

The special properties of fluorine atoms and fluorine-containing groups have led to an increasing number of applications for fluorine-containing organic compounds, which are also extremely widely used in the field of new drug development. Unfortunately, naturally fluorinated organics are rare in nature, so the selective introduction of fluorine atoms or fluorine-containing groups into organic molecules is very important for pharmaceutical/synthetic chemists. N-2,2,2-trifluoroethylisatin ketimines have received the attention of many chemists since they were first developed as fluorine-containing synthons in 2015. This paper reviews the organic synthesis reactions in which trifluoroethyl isatin ketimine has been involved in recent years, focusing on the types of reactions and the stereoselectivity of products, and also provides a prospect of its application in this field.
Keywords: N-2,2,2-trifluoroethylisatin ketimine; trifluoromethyl; cycloaddition; organic synthesis; cascade reaction N-2,2,2-trifluoroethylisatin ketimine; trifluoromethyl; cycloaddition; organic synthesis; cascade reaction

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MDPI and ACS Style

Liu, Y.; Wang, L.; Ma, D.; Song, Y. Recent Advances of N-2,2,2-Trifluoroethylisatin Ketimines in Organic Synthesis. Molecules 2023, 28, 2990. https://doi.org/10.3390/molecules28072990

AMA Style

Liu Y, Wang L, Ma D, Song Y. Recent Advances of N-2,2,2-Trifluoroethylisatin Ketimines in Organic Synthesis. Molecules. 2023; 28(7):2990. https://doi.org/10.3390/molecules28072990

Chicago/Turabian Style

Liu, Yuting, Lijie Wang, Donglai Ma, and Yongxing Song. 2023. "Recent Advances of N-2,2,2-Trifluoroethylisatin Ketimines in Organic Synthesis" Molecules 28, no. 7: 2990. https://doi.org/10.3390/molecules28072990

APA Style

Liu, Y., Wang, L., Ma, D., & Song, Y. (2023). Recent Advances of N-2,2,2-Trifluoroethylisatin Ketimines in Organic Synthesis. Molecules, 28(7), 2990. https://doi.org/10.3390/molecules28072990

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