Extended-Synaptotagmin 1 Enhances Liver Cancer Progression Mediated by the Unconventional Secretion of Cytosolic Proteins
Abstract
:1. Introduction
2. Results
2.1. E-Syt1 Affects Growth of Liver Cancer Cells
2.2. E-Syt1 Contributes to PKCδ Secretion in Liver Cancer Cell Lines
2.3. E-Syt1 Is Involved in the Activation of PKCδ-IGF1R Signaling
2.4. E-Syt1 Is Involved in Liver Cancer Tumorigenesis
3. Materials and Methods
4. Discussion and Conclusions
Supplementary Materials
Author Contributions
Funding
Institutional Review Board Statement
Informed Consent Statement
Data Availability Statement
Acknowledgments
Conflicts of Interest
Sample Availability
Abbreviations
E-Syt1 | Extended-synaptotagmin 1 |
PKCδ | protein kinase C delta |
HCC | hepatocellular carcinoma |
IGF1R | insulin-like growth factor 1 receptor |
Erk1/2 | extracellular-signal-related kinase ½ |
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Yamada, K.; Hannya, Y.; Oikawa, T.; Yoshida, A.; Katagiri, K.; Yoshida, S.; Koizumi, R.; Tago, N.; Shimoyama, Y.; Kawamura, A.; et al. Extended-Synaptotagmin 1 Enhances Liver Cancer Progression Mediated by the Unconventional Secretion of Cytosolic Proteins. Molecules 2023, 28, 4033. https://doi.org/10.3390/molecules28104033
Yamada K, Hannya Y, Oikawa T, Yoshida A, Katagiri K, Yoshida S, Koizumi R, Tago N, Shimoyama Y, Kawamura A, et al. Extended-Synaptotagmin 1 Enhances Liver Cancer Progression Mediated by the Unconventional Secretion of Cytosolic Proteins. Molecules. 2023; 28(10):4033. https://doi.org/10.3390/molecules28104033
Chicago/Turabian StyleYamada, Kohji, Yoshito Hannya, Tsunekazu Oikawa, Ayano Yoshida, Kuniko Katagiri, Saishu Yoshida, Rei Koizumi, Naoko Tago, Yuya Shimoyama, Akira Kawamura, and et al. 2023. "Extended-Synaptotagmin 1 Enhances Liver Cancer Progression Mediated by the Unconventional Secretion of Cytosolic Proteins" Molecules 28, no. 10: 4033. https://doi.org/10.3390/molecules28104033