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Genetic Manipulation and Bioreactor Culture of Plants as a Tool for Industry and Its Applications

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Department of Molecular Biotechnology and Genetics, University of Lodz, 90-237 Lodz, Poland
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Department of Economic Informatics, University of Lodz, 90-214 Lodz, Poland
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Littoral Environnement et Sociétés UMRi CNRS 7266 LIENSs, La Rochelle Université, 17042 La Rochelle, France
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Analytical Toxicology and Mineral Metabolism Unit, Institute for Medical Research and Occupational Health, 10000 Zagreb, Croatia
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Department of Immunopathology, Medical University of Lodz, 90-752 Lodz, Poland
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Laboratory of Medical Genetics, Faculty of Biology and Environmental Protection, University of Lodz, 90-236 Lodz, Poland
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Department of Biology and Pharmaceutical Botany, Medical University of Lodz, 90-151 Lodz, Poland
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Authors to whom correspondence should be addressed.
Academic Editor: André Chwalibog
Molecules 2022, 27(3), 795; https://doi.org/10.3390/molecules27030795
Received: 14 December 2021 / Revised: 15 January 2022 / Accepted: 20 January 2022 / Published: 25 January 2022
In recent years, there has been a considerable increase in interest in the use of transgenic plants as sources of valuable secondary metabolites or recombinant proteins. This has been facilitated by the advent of genetic engineering technology with the possibility for direct modification of the expression of genes related to the biosynthesis of biologically active compounds. A wide range of research projects have yielded a number of efficient plant systems that produce specific secondary metabolites or recombinant proteins. Furthermore, the use of bioreactors allows production to be increased to industrial scales, which can quickly and cheaply deliver large amounts of material in a short time. The resulting plant production systems can function as small factories, and many of them that are targeted at a specific operation have been patented. This review paper summarizes the key research in the last ten years regarding the use of transgenic plants as small, green biofactories for the bioreactor-based production of secondary metabolites and recombinant proteins; it simultaneously examines the production of metabolites and recombinant proteins on an industrial scale and presents the current state of available patents in the field. View Full-Text
Keywords: bioreactors; genetic manipulation; patents; recombinant proteins; secondary metabolites; transgenic plant cultures bioreactors; genetic manipulation; patents; recombinant proteins; secondary metabolites; transgenic plant cultures
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MDPI and ACS Style

Kowalczyk, T.; Merecz-Sadowska, A.; Picot, L.; Brčić Karačonji, I.; Wieczfinska, J.; Śliwiński, T.; Sitarek, P. Genetic Manipulation and Bioreactor Culture of Plants as a Tool for Industry and Its Applications. Molecules 2022, 27, 795. https://doi.org/10.3390/molecules27030795

AMA Style

Kowalczyk T, Merecz-Sadowska A, Picot L, Brčić Karačonji I, Wieczfinska J, Śliwiński T, Sitarek P. Genetic Manipulation and Bioreactor Culture of Plants as a Tool for Industry and Its Applications. Molecules. 2022; 27(3):795. https://doi.org/10.3390/molecules27030795

Chicago/Turabian Style

Kowalczyk, Tomasz, Anna Merecz-Sadowska, Laurent Picot, Irena Brčić Karačonji, Joanna Wieczfinska, Tomasz Śliwiński, and Przemysław Sitarek. 2022. "Genetic Manipulation and Bioreactor Culture of Plants as a Tool for Industry and Its Applications" Molecules 27, no. 3: 795. https://doi.org/10.3390/molecules27030795

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