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Different Schiff Bases—Structure, Importance and Classification

Carbohydrate Chemistry Group, Faculty of Chemistry, University of Gdańsk, Wita Stwosza 63, 80-308 Gdańsk, Poland
Author to whom correspondence should be addressed.
Academic Editors: Isabella Rimoldi and Giorgio Facchetti
Molecules 2022, 27(3), 787;
Received: 17 December 2021 / Revised: 14 January 2022 / Accepted: 14 January 2022 / Published: 25 January 2022
(This article belongs to the Special Issue The Chemistry of Imines)
Schiff bases are a vast group of compounds characterized by the presence of a double bond linking carbon and nitrogen atoms, the versatility of which is generated in the many ways to combine a variety of alkyl or aryl substituents. Compounds of this type are both found in nature and synthesized in the laboratory. For years, Schiff bases have been greatly inspiring to many chemists and biochemists. In this article, we attempt to present a new take on this group of compounds, underlining of the importance of various types of Schiff bases. Among the different types of compounds that can be classified as Schiff bases, we chose hydrazides, dihydrazides, hydrazones and mixed derivatives such as hydrazide–hydrazones. For these compounds, we presented the elements of their structure that allow them to be classified as Schiff bases. While hydrazones are typical examples of Schiff bases, including hydrazides among them may be surprising for some. In their case, this is possible due to the amide-iminol tautomerism. The carbon–nitrogen double bond present in the iminol tautomer is a typical element found in Schiff bases. In addition to the characteristics of the structure of these selected derivatives, and sometimes their classification, we presented selected literature items which, in our opinion, represent their importance in various fields well. View Full-Text
Keywords: Schiff bases; hydrazides; dihydrazides; hydrazones; hydrazide–hydrazones Schiff bases; hydrazides; dihydrazides; hydrazones; hydrazide–hydrazones
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MDPI and ACS Style

Raczuk, E.; Dmochowska, B.; Samaszko-Fiertek, J.; Madaj, J. Different Schiff Bases—Structure, Importance and Classification. Molecules 2022, 27, 787.

AMA Style

Raczuk E, Dmochowska B, Samaszko-Fiertek J, Madaj J. Different Schiff Bases—Structure, Importance and Classification. Molecules. 2022; 27(3):787.

Chicago/Turabian Style

Raczuk, Edyta, Barbara Dmochowska, Justyna Samaszko-Fiertek, and Janusz Madaj. 2022. "Different Schiff Bases—Structure, Importance and Classification" Molecules 27, no. 3: 787.

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