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Review

Natural Dietary Compounds in the Treatment of Arsenic Toxicity

by
Geir Bjørklund
1,*,
Md. Shiblur Rahaman
2,3,
Mariia Shanaida
4,
Roman Lysiuk
5,6,
Petro Oliynyk
7,
Larysa Lenchyk
8,9,
Salvatore Chirumbolo
10,11,
Christos T. Chasapis
12 and
Massimiliano Peana
13,*
1
Council for Nutritional and Environmental Medicine, Toften 24, 8610 Mo i Rana, Norway
2
Department of Environmental and Preventive Medicine, Jichi Medical University School of Medicine, Shimotsuke 329-0498, Japan
3
Graduate School of Environmental Science, Hokkaido University, Sapporo 060-0810, Japan
4
Department of Pharmacognosy and Medical Botany, I. Horbachevsky Ternopil National Medical University, 46001 Ternopil, Ukraine
5
Department of Pharmacognosy and Botany, Danylo Halytsky Lviv National Medical University, 79010 Lviv, Ukraine
6
CONEM Ukraine Life Science Research Group, Danylo Halytsky Lviv National Medical University, 79010 Lviv, Ukraine
7
Department of Disaster Medicine and Military Medicine, Danylo Halytsky Lviv National Medical University, 79010 Lviv, Ukraine
8
Department of Chemistry of Natural Compounds, National University of Pharmacy, 61002 Kharkiv, Ukraine
9
CONEM Ukraine Pharmacognosy and Natural Product Chemistry Research Group, National University of Pharmacy, 61002 Kharkiv, Ukraine
10
Department of Neurosciences, Biomedicine and Movement Sciences, University of Verona, 37134 Verona, Italy
11
CONEM Scientific Secretary, strada Le Grazie 9, 37134 Verona, Italy
12
NMR Facility, Instrumental Analysis Laboratory, School of Natural Sciences, University of Patras, 265 04 Patras, Greece
13
Department of Chemical, Physics, Mathematics and Natural Sciences, University of Sassari, Via Vienna 2, 07100 Sassari, Italy
 
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Authors to whom correspondence should be addressed.
Molecules 2022, 27(15), 4871; https://doi.org/10.3390/molecules27154871
Submission received: 30 June 2022 / Revised: 23 July 2022 / Accepted: 27 July 2022 / Published: 29 July 2022
(This article belongs to the Special Issue Discovery of Bioactive Ingredients from Natural Products, 2nd Edition)
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Abstract

Chronic exposure to arsenic (As) compounds leads to its accumulation in the body, with skin lesions and cancer being the most typical outcomes. Treating As-induced diseases continues to be challenging as there is no specific, safe, and efficacious therapeutic management. Therapeutic and preventive measures available to combat As toxicity refer to chelation therapy, antioxidant therapy, and the intake of natural dietary compounds. Although chelation therapy is the most commonly used method for detoxifying As, it has several side effects resulting in various toxicities such as hepatotoxicity, neurotoxicity, and other adverse consequences. Drugs of plant origin and natural dietary compounds show efficient and progressive relief from As-mediated toxicity without any particular side effects. These natural compounds have also been found to aid the elimination of As from the body and, therefore, can be more effective than conventional therapeutic agents in ameliorating As toxicity. This review provides an overview of the recently updated knowledge on treating As poisoning through natural dietary compounds. This updated information may serve as a basis for defining novel prophylactic and therapeutic formulations.
Keywords: arsenic; toxicity; natural compounds; vitamins; trace elements; medicinal plants arsenic; toxicity; natural compounds; vitamins; trace elements; medicinal plants

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MDPI and ACS Style

Bjørklund, G.; Rahaman, M.S.; Shanaida, M.; Lysiuk, R.; Oliynyk, P.; Lenchyk, L.; Chirumbolo, S.; Chasapis, C.T.; Peana, M. Natural Dietary Compounds in the Treatment of Arsenic Toxicity. Molecules 2022, 27, 4871. https://doi.org/10.3390/molecules27154871

AMA Style

Bjørklund G, Rahaman MS, Shanaida M, Lysiuk R, Oliynyk P, Lenchyk L, Chirumbolo S, Chasapis CT, Peana M. Natural Dietary Compounds in the Treatment of Arsenic Toxicity. Molecules. 2022; 27(15):4871. https://doi.org/10.3390/molecules27154871

Chicago/Turabian Style

Bjørklund, Geir, Md. Shiblur Rahaman, Mariia Shanaida, Roman Lysiuk, Petro Oliynyk, Larysa Lenchyk, Salvatore Chirumbolo, Christos T. Chasapis, and Massimiliano Peana. 2022. "Natural Dietary Compounds in the Treatment of Arsenic Toxicity" Molecules 27, no. 15: 4871. https://doi.org/10.3390/molecules27154871

APA Style

Bjørklund, G., Rahaman, M. S., Shanaida, M., Lysiuk, R., Oliynyk, P., Lenchyk, L., Chirumbolo, S., Chasapis, C. T., & Peana, M. (2022). Natural Dietary Compounds in the Treatment of Arsenic Toxicity. Molecules, 27(15), 4871. https://doi.org/10.3390/molecules27154871

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