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Pharmacological, Neurochemical, and Behavioral Mechanisms Underlying the Anxiolytic- and Antidepressant-like Effects of Flavonoid Chrysin

1
Laboratorio de Neurofarmacología, Instituto de Neuroetología, Universidad Veracruzana, Xalapa 91190, Mexico
2
Facultad de Química Farmacéutica Biológica, Universidad Veracruzana, Xalapa 91000, Mexico
3
Unidad de Salud Integrativa, Centro de EcoAlfabetización y Diálogo de Saberes, Universidad Veracruzana, Xalapa 91060, Mexico
*
Author to whom correspondence should be addressed.
Academic Editors: Duangjai Tungmunnithum, Youhei Sasaki and Aekkhaluck Intharuksa
Molecules 2022, 27(11), 3551; https://doi.org/10.3390/molecules27113551
Received: 23 April 2022 / Revised: 27 May 2022 / Accepted: 27 May 2022 / Published: 31 May 2022
Chrysin (5,7-dihydroxyflavone) is a flavonoid isolated from plants, such as Passiflora coerulea, Passiflora incarnata, and Matricaria chamomilla. This natural molecule exerts diverse pharmacological effects, which includes antioxidant, anti-inflammatory, anti-cancer, neuroprotective, and anti-apoptotic effects. Additionally, in brain structures, such as the hippocampus, prefrontal cortex, raphe nucleus, and striatum, involved in the physiopathology of anxiety and depression disorders, several neuropharmacological activities, including the activation of neurotransmitter systems (GABAergic, serotonergic, dopaminergic, and noradrenergic), neurotrophic factors, such as brain-derived neurotrophic factor and the nerve growth factor, and some signaling pathways are affected. The results showed that the anxiolytic and antidepressant-like effects of chrysin occurs through its interaction with specific neurotransmitter systems, principally the GABAergic and the serotonergic, and activation of other neurotrophic factors. However, it is not possible to discard the antioxidant and anti-inflammatory activities of chrysin while producing its anxiolytic- and antidepressant-like effects. Although these results have been obtained principally from pre-clinical research, they consistently demonstrate the potential therapeutic use of flavonoid chrysin as an anxiolytic and antidepressant agent. Therefore, this flavonoid could be considered as a promising novel therapy for anxiety and depression disorders. View Full-Text
Keywords: antidepressant; anxiolytic; chrysin; flavonoid; natural medicine; neuropharmacology antidepressant; anxiolytic; chrysin; flavonoid; natural medicine; neuropharmacology
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MDPI and ACS Style

Rodríguez-Landa, J.F.; German-Ponciano, L.J.; Puga-Olguín, A.; Olmos-Vázquez, O.J. Pharmacological, Neurochemical, and Behavioral Mechanisms Underlying the Anxiolytic- and Antidepressant-like Effects of Flavonoid Chrysin. Molecules 2022, 27, 3551. https://doi.org/10.3390/molecules27113551

AMA Style

Rodríguez-Landa JF, German-Ponciano LJ, Puga-Olguín A, Olmos-Vázquez OJ. Pharmacological, Neurochemical, and Behavioral Mechanisms Underlying the Anxiolytic- and Antidepressant-like Effects of Flavonoid Chrysin. Molecules. 2022; 27(11):3551. https://doi.org/10.3390/molecules27113551

Chicago/Turabian Style

Rodríguez-Landa, Juan Francisco, León Jesús German-Ponciano, Abraham Puga-Olguín, and Oscar Jerónimo Olmos-Vázquez. 2022. "Pharmacological, Neurochemical, and Behavioral Mechanisms Underlying the Anxiolytic- and Antidepressant-like Effects of Flavonoid Chrysin" Molecules 27, no. 11: 3551. https://doi.org/10.3390/molecules27113551

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