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Comparative Study on Curcumin Loaded in Golden Pompano (Trachinotus blochii) Head Phospholipid and Soybean Lecithin Liposomes: Preparation, Characteristics and Anti-Inflammatory Properties

by 1,2, 1,2, 1,2,3,4, 3, 1,2,3,4, 1,2,3,4,* and 1,2,3,4,*
1
Hainan Engineering Research Center of Aquatic Resources Efficient Utilization in South China Sea, Hainan University, Hainan 570228, China
2
College of Food Science and Technology, Hainan University, Hainan 570228, China
3
Collaborative Innovation Center of seafood Deep Processing, Dalian Polytechnic University, Dalian 116000, China
4
Key Laboratory of Seafood Processing of Haikou, Hainan 570228, China
*
Authors to whom correspondence should be addressed.
Academic Editor: Luigi Paduano
Molecules 2021, 26(8), 2328; https://doi.org/10.3390/molecules26082328
Received: 3 March 2021 / Revised: 10 April 2021 / Accepted: 13 April 2021 / Published: 16 April 2021
In this study, we compared the characteristics and in vitro anti-inflammatory effects of two curcumin liposomes, prepared with golden pompano head phospholipids (GPL) and soybean lecithin (SPC). GPL liposomes (GPL-lipo) and SPC liposomes (SPC-lipo) loaded with curcumin (CUR) were prepared by thin film extrusion, and the differences in particle size, ζ-potential, morphology, and storage stability were investigated. The results show that GPL-lipo and SPC-lipo were monolayer liposomes with a relatively small particle size and excellent encapsulation rates. However, GPL-lipo displayed a larger negative ζ-potential and better storage stability compared to SPC-lipo. Subsequently, the effects of phospholipids in regulating the inflammatory response of macrophages were evaluated in vitro, based on the synergistic effect with CUR. The results showed that both GPL and SPC exerted excellent synergistic effect with CUR in inhibiting the lipopolysaccharide (LPS)-induced secretion of nitric oxide (NO), reactive oxygen species (ROS), and pro-inflammatory genes (tumor necrosis factor (TNF)-α, interleukin 1β (IL-β), and interleukin 6 (IL-6)) in RAW264.7 cells. Interestingly, GPL-lipo displayed superior inhibitory effects, compared to SPC-lipo. The findings provide a new innovative bioactive carrier for development of stable CUR liposomes with good functional properties. View Full-Text
Keywords: curcumin; fish head phospholipid; liposomes; inflammation curcumin; fish head phospholipid; liposomes; inflammation
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MDPI and ACS Style

Gao, X.; Yi, X.; Liu, Z.; Dong, X.; Xia, G.; Zhang, X.; Shen, X. Comparative Study on Curcumin Loaded in Golden Pompano (Trachinotus blochii) Head Phospholipid and Soybean Lecithin Liposomes: Preparation, Characteristics and Anti-Inflammatory Properties. Molecules 2021, 26, 2328. https://doi.org/10.3390/molecules26082328

AMA Style

Gao X, Yi X, Liu Z, Dong X, Xia G, Zhang X, Shen X. Comparative Study on Curcumin Loaded in Golden Pompano (Trachinotus blochii) Head Phospholipid and Soybean Lecithin Liposomes: Preparation, Characteristics and Anti-Inflammatory Properties. Molecules. 2021; 26(8):2328. https://doi.org/10.3390/molecules26082328

Chicago/Turabian Style

Gao, Xia, Xiangzhou Yi, Zhongyuan Liu, Xiuping Dong, Guanghua Xia, Xueying Zhang, and Xuanri Shen. 2021. "Comparative Study on Curcumin Loaded in Golden Pompano (Trachinotus blochii) Head Phospholipid and Soybean Lecithin Liposomes: Preparation, Characteristics and Anti-Inflammatory Properties" Molecules 26, no. 8: 2328. https://doi.org/10.3390/molecules26082328

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