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Open AccessArticle

Mealworm Oil (MWO) Enhances Wound Healing Potential through the Activation of Fibroblast and Endothelial Cells

1
Department of Biomedical Laboratory Science, TaeKyeung University, 65, Danbuk 1-gil, Jain-myeon, Gyeongsan-si, Gyeongsangbuk-do 38547, Korea
2
APROGEN, Inc., 545, Dunchon-daero, Jungwon-gu, Seongnam-si, Gyeonggi-do 13215, Korea
3
Department of Plastic and Reconstructive Surgery, Yeungnam University College of Medicine, 170, Hyeonchung-ro, Nam-gu, Daegu 42415, Korea
4
JIN BioCell Co., Ltd., #118-119, National Clinical Research Center for Korean Medicine, Pusan National University Korean Medicine Hospital, 20 Geumo-ro, Mulgeum-eup, Yangsan-si, Gyeongsangnam-do 50612, Korea
*
Authors to whom correspondence should be addressed.
These authors contributed equally to this article.
Academic Editor: Maurizio Battino
Molecules 2021, 26(4), 779; https://doi.org/10.3390/molecules26040779
Received: 5 January 2021 / Revised: 23 January 2021 / Accepted: 29 January 2021 / Published: 3 February 2021
Mealworm and mealworm oil (MWO) have been reported to affect antioxidant, anti-coagulation, anti-adipogenic and anti-inflammatory activities. However, the function of MWO in wound healing is still unclear. In this study, we found that MWO induced the migration of fibroblast cells and mRNA expressions of wound healing factors such as alpha-smooth muscle actin (α-SMA), collagen-1 (COL-1) and vascular endothelial growth factor (VEGF) in fibroblast cells. The tube formation and migration of endothelial cells were promoted through the activation of VEGF/VEGF receptor-2 (VEGFR-2)-mediated downstream signals including AKT, extracellular signal-regulated kinase (ERK) and p38 by MWO-stimulated fibroblasts for angiogenesis. Moreover, we confirmed that MWO promoted skin wound repair by collagen synthesis, re-epithelialization and angiogenesis in an in vivo excisional wound model. These results demonstrate that MWO might have potential as a therapeutic agent for the treatment of skin wounds. View Full-Text
Keywords: mealworm oil; wound healing; fibroblasts; endothelial cells; migration mealworm oil; wound healing; fibroblasts; endothelial cells; migration
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MDPI and ACS Style

Kim, J.-H.; Kim, E.-Y.; Chung, K.J.; Lee, J.-H.; Choi, H.-J.; Chung, T.-W.; Kim, K.-J. Mealworm Oil (MWO) Enhances Wound Healing Potential through the Activation of Fibroblast and Endothelial Cells. Molecules 2021, 26, 779. https://doi.org/10.3390/molecules26040779

AMA Style

Kim J-H, Kim E-Y, Chung KJ, Lee J-H, Choi H-J, Chung T-W, Kim K-J. Mealworm Oil (MWO) Enhances Wound Healing Potential through the Activation of Fibroblast and Endothelial Cells. Molecules. 2021; 26(4):779. https://doi.org/10.3390/molecules26040779

Chicago/Turabian Style

Kim, Joung-Hee; Kim, Eun-Yeong; Chung, Kyu J.; Lee, Jung-Hee; Choi, Hee-Jung; Chung, Tae-Wook; Kim, Keuk-Jun. 2021. "Mealworm Oil (MWO) Enhances Wound Healing Potential through the Activation of Fibroblast and Endothelial Cells" Molecules 26, no. 4: 779. https://doi.org/10.3390/molecules26040779

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