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10.3390/molecules26206168
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Review

Shedding Light on the Pharmacological Interactions between μ-Opioid Analgesics and Angiotensin Receptor Modulators: A New Option for Treating Chronic Pain

by
Kornél Király
1,*,†,
Dávid Á. Karádi
1,†,
Ferenc Zádor
1,2,
Amir Mohammadzadeh
1,
Anna Rita Galambos
1,
Mihály Balogh
1,
Pál Riba
1,
Tamás Tábi
2,
Zoltán S. Zádori
1,
Éva Szökő
2,
Susanna Fürst
1 and
Mahmoud Al-Khrasani
1,*
1
Department of Pharmacology and Pharmacotherapy, Faculty of Medicine, Semmelweis University, Nagyvárad tér 4, P.O. Box 370, H-1445 Budapest, Hungary
2
Department of Pharmacodynamics, Faculty of Pharmacy, Semmelweis University, Nagyvárad tér 4, H-1089 Budapest, Hungary
*
Authors to whom correspondence should be addressed.
†
These authors equally contributed to this work.
Molecules 2021, 26(20), 6168; https://doi.org/10.3390/molecules26206168
Submission received: 15 September 2021 / Revised: 5 October 2021 / Accepted: 8 October 2021 / Published: 13 October 2021
(This article belongs to the Special Issue Opioids and Their Receptors: Present and Emerging Concepts in Opioid Drug Discovery II)
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Abstract

The current protocols for neuropathic pain management include µ-opioid receptor (MOR) analgesics alongside other drugs; however, there is debate on the effectiveness of opioids. Nevertheless, dose escalation is required to maintain their analgesia, which, in turn, contributes to a further increase in opioid side effects. Finding novel approaches to effectively control chronic pain, particularly neuropathic pain, is a great challenge clinically. Literature data related to pain transmission reveal that angiotensin and its receptors (the AT1R, AT2R, and MAS receptors) could affect the nociception both in the periphery and CNS. The MOR and angiotensin receptors or drugs interacting with these receptors have been independently investigated in relation to analgesia. However, the interaction between the MOR and angiotensin receptors has not been excessively studied in chronic pain, particularly neuropathy. This review aims to shed light on existing literature information in relation to the analgesic action of AT1R and AT2R or MASR ligands in neuropathic pain conditions. Finally, based on literature data, we can hypothesize that combining MOR agonists with AT1R or AT2R antagonists might improve analgesia.
Keywords: µ-opioid analgesics; angiotensin receptors; chronic pain; neuropathic pain µ-opioid analgesics; angiotensin receptors; chronic pain; neuropathic pain

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MDPI and ACS Style

Király, K.; Karádi, D.Á.; Zádor, F.; Mohammadzadeh, A.; Galambos, A.R.; Balogh, M.; Riba, P.; Tábi, T.; Zádori, Z.S.; Szökő, É.; et al. Shedding Light on the Pharmacological Interactions between μ-Opioid Analgesics and Angiotensin Receptor Modulators: A New Option for Treating Chronic Pain. Molecules 2021, 26, 6168. https://doi.org/10.3390/molecules26206168

AMA Style

Király K, Karádi DÁ, Zádor F, Mohammadzadeh A, Galambos AR, Balogh M, Riba P, Tábi T, Zádori ZS, Szökő É, et al. Shedding Light on the Pharmacological Interactions between μ-Opioid Analgesics and Angiotensin Receptor Modulators: A New Option for Treating Chronic Pain. Molecules. 2021; 26(20):6168. https://doi.org/10.3390/molecules26206168

Chicago/Turabian Style

Király, Kornél, Dávid Á. Karádi, Ferenc Zádor, Amir Mohammadzadeh, Anna Rita Galambos, Mihály Balogh, Pál Riba, Tamás Tábi, Zoltán S. Zádori, Éva Szökő, and et al. 2021. "Shedding Light on the Pharmacological Interactions between μ-Opioid Analgesics and Angiotensin Receptor Modulators: A New Option for Treating Chronic Pain" Molecules 26, no. 20: 6168. https://doi.org/10.3390/molecules26206168

APA Style

Király, K., Karádi, D. Á., Zádor, F., Mohammadzadeh, A., Galambos, A. R., Balogh, M., Riba, P., Tábi, T., Zádori, Z. S., Szökő, É., Fürst, S., & Al-Khrasani, M. (2021). Shedding Light on the Pharmacological Interactions between μ-Opioid Analgesics and Angiotensin Receptor Modulators: A New Option for Treating Chronic Pain. Molecules, 26(20), 6168. https://doi.org/10.3390/molecules26206168

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