Study on the CID Fragmentation Pathways of Deprotonated 4’-Monophosphoryl Lipid A
Abstract
:1. Introduction
2. Results and Discussion
2.1. MS2 Mass Spectra of the [M − H]− Lipid A Precursor Ions
2.2. Proposed Mechanisms for the Release of the Secondary Fatty Acids
2.3. Proposed Mechanisms for the Release of the Primary Fatty Acids
2.4. Cross-ring Fragmentations
2.5. Dephosphorylation
3. Experimental
3.1. Chemicals
3.2. Lipid A Samples
3.3. Lipid A Sample Preparation
3.4. Mass Spectrometric Analysis
3.5. Data Evaluation
4. Conclusions
Supplementary Materials
Author Contributions
Funding
Institutional Review Board Statement
Informed Consent Statement
Data Availability Statement
Acknowledgments
Conflicts of Interest
Sample Availability
References
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Aissa, I.; Kilár, A.; Dörnyei, Á. Study on the CID Fragmentation Pathways of Deprotonated 4’-Monophosphoryl Lipid A. Molecules 2021, 26, 5961. https://doi.org/10.3390/molecules26195961
Aissa I, Kilár A, Dörnyei Á. Study on the CID Fragmentation Pathways of Deprotonated 4’-Monophosphoryl Lipid A. Molecules. 2021; 26(19):5961. https://doi.org/10.3390/molecules26195961
Chicago/Turabian StyleAissa, Ibrahim, Anikó Kilár, and Ágnes Dörnyei. 2021. "Study on the CID Fragmentation Pathways of Deprotonated 4’-Monophosphoryl Lipid A" Molecules 26, no. 19: 5961. https://doi.org/10.3390/molecules26195961