Ergosta-7,9(11),22-trien-3β-ol Rescues AD Deficits by Modulating Microglia Activation but Not Oxidative Stress
Abstract
:1. Introduction
2. Results
2.1. Ergosta-7,9(11),22-trien-3β-ol Rescued Survival and Climbing of AD Drosophila
2.2. Ergosta-7,9(11),22-trien-3β-ol Rescued Learning and One-Hour Memory of AD Drosophila
2.3. Ergosta-7,9(11),22-trien-3β-ol Modulated Microglial Activation in AD Drosophila
2.4. Ergosta-7,9(11),22-trien-3β-ol Did Not Modulate Ubiquitous Oxidative Stress in AD Drosophila
3. Discussion
4. Materials and Methods
4.1. Fly Stock Maintenance and Lifespan Measurement
4.2. Ergosta-7,9(11),22-trien-3β-ol (Ek100)
4.3. Antigeotaxis Assays
4.4. Drosophila Learning and Memory Platform (T-Maze)
4.5. Quantitative PCR
4.6. Oxidative Stress Assays
4.7. Statistic Analysis
5. Conclusions
Supplementary Materials
Author Contributions
Funding
Institutional Review Board Statement
Informed Consent Statement
Data Availability Statement
Conflicts of Interest
Sample Availability
References
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Liu, H.-P.; Kuo, Y.-H.; Cheng, J.; Chang, L.-Z.; Chang, M.-S.; Su, L.-W.; Chuang, T.-N.; Lin, W.-Y. Ergosta-7,9(11),22-trien-3β-ol Rescues AD Deficits by Modulating Microglia Activation but Not Oxidative Stress. Molecules 2021, 26, 5338. https://doi.org/10.3390/molecules26175338
Liu H-P, Kuo Y-H, Cheng J, Chang L-Z, Chang M-S, Su L-W, Chuang T-N, Lin W-Y. Ergosta-7,9(11),22-trien-3β-ol Rescues AD Deficits by Modulating Microglia Activation but Not Oxidative Stress. Molecules. 2021; 26(17):5338. https://doi.org/10.3390/molecules26175338
Chicago/Turabian StyleLiu, Hsin-Ping, Yueh-Hsiung Kuo, Jack Cheng, Li-Zhong Chang, Meng-Shiun Chang, Li-Wen Su, Tsai-Ni Chuang, and Wei-Yong Lin. 2021. "Ergosta-7,9(11),22-trien-3β-ol Rescues AD Deficits by Modulating Microglia Activation but Not Oxidative Stress" Molecules 26, no. 17: 5338. https://doi.org/10.3390/molecules26175338