Next Article in Journal
The Effect of High Fat Diet on Cerebrovascular Health and Pathology: A Species Comparative Review
Next Article in Special Issue
Polyphenols and Human Beings: From Epidemiology to Molecular Targets
Previous Article in Journal
Resistant Starch Contents of Starch Isolated from Black Longan Seeds
Previous Article in Special Issue
A Red-Berry Mixture as a Nutraceutical: Detailed Composition and Neuronal Protective Effect
Review

Polyphenols and Visual Health: Potential Effects on Degenerative Retinal Diseases

Grup de Biotecnologia Molecular i Industrial, Centre de Biotecnologia Molecular, Departament d’Enginyeria Química, Universitat Politècnica de Catalunya, Edifici Gaia, 08222 Terrassa, Spain
*
Author to whom correspondence should be addressed.
These authors contributed equally to the work.
Academic Editors: Celestino Santos-Buelga and Francesco Cacciola
Molecules 2021, 26(11), 3407; https://doi.org/10.3390/molecules26113407
Received: 26 April 2021 / Revised: 1 June 2021 / Accepted: 2 June 2021 / Published: 4 June 2021
(This article belongs to the Special Issue Polyphenols and Human Being: From Epidemiology to Molecular Targets)
Dietary polyphenols are a group of natural compounds that have been proposed to have beneficial effects on human health. They were first known for their antioxidant properties, but several studies over the years have shown that these compounds can exert protective effects against chronic diseases. Nonetheless, the mechanisms underlying these potential benefits are still uncertain and contradictory effects have been reported. In this review, we analyze the potential effects of polyphenol compounds on some visual diseases, with a special focus on retinal degenerative diseases. Current effective therapies for the treatment of such retinal diseases are lacking and new strategies need to be developed. For this reason, there is currently a renewed interest in finding novel ligands (or known ligands with previously unexpected features) that could bind to retinal photoreceptors and modulate their molecular properties. Some polyphenols, especially flavonoids (e.g., quercetin and tannic acid), could attenuate light-induced receptor damage and promote visual health benefits. Recent evidence suggests that certain flavonoids could help stabilize the correctly folded conformation of the visual photoreceptor protein rhodopsin and offset the deleterious effect of retinitis pigmentosa mutations. In this regard, certain polyphenols, like the flavonoids mentioned before, have been shown to improve the stability, expression, regeneration and folding of rhodopsin mutants in experimental in vitro studies. Moreover, these compounds appear to improve the integration of the receptor into the cell membrane while acting against oxidative stress at the same time. We anticipate that polyphenol compounds can be used to target visual photoreceptor proteins, such as rhodopsin, in a way that has only been recently proposed and that these can be used in novel approaches for the treatment of retinal degenerative diseases like retinitis pigmentosa; however, studies in this field are limited and further research is needed in order to properly characterize the effects of these compounds on retinal degenerative diseases through the proposed mechanisms. View Full-Text
Keywords: flavonoids; retinal degenerative diseases; retinitis pigmentosa; protein folding; ligand binding; rhodopsin flavonoids; retinal degenerative diseases; retinitis pigmentosa; protein folding; ligand binding; rhodopsin
Show Figures

Figure 1

MDPI and ACS Style

Fernandez-Gonzalez, P.; Mas-Sanchez, A.; Garriga, P. Polyphenols and Visual Health: Potential Effects on Degenerative Retinal Diseases. Molecules 2021, 26, 3407. https://doi.org/10.3390/molecules26113407

AMA Style

Fernandez-Gonzalez P, Mas-Sanchez A, Garriga P. Polyphenols and Visual Health: Potential Effects on Degenerative Retinal Diseases. Molecules. 2021; 26(11):3407. https://doi.org/10.3390/molecules26113407

Chicago/Turabian Style

Fernandez-Gonzalez, Pol, Aina Mas-Sanchez, and Pere Garriga. 2021. "Polyphenols and Visual Health: Potential Effects on Degenerative Retinal Diseases" Molecules 26, no. 11: 3407. https://doi.org/10.3390/molecules26113407

Find Other Styles
Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Article Access Map by Country/Region

1
Back to TopTop