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Article

Efficacy of Caffeic Acid on Diabetes and Its Complications in the Mouse

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Department of Animal Physiology, Faculty of Science, University of Zagreb, Rooseveltov trg 6, HR-10000 Zagreb, Croatia
2
Mutagenesis Unit, Institute for Medical Research and Occupational Health, HR-10000 Zagreb, Croatia
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Department of Biochemical Engineering, Faculty of Food Technology and Biotechnology, University of Zagreb, Pierottijeva 6, HR-10000 Zagreb, Croatia
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Laboratory for Protein Dynamics, Division of Molecular Medicine, Ruđer Bošković Institute, Bijenička Cesta 54, HR-10 000 Zagreb, Croatia
5
Department of Psychology, Catholic University of Croatia, Ilica 242, HR-10000 Zagreb, Croatia
*
Author to whom correspondence should be addressed.
Academic Editors: Marisa Freitas, Daniela Ribeiro, Eduarda Fernandes and Lars Porskjær Christensen
Molecules 2021, 26(11), 3262; https://doi.org/10.3390/molecules26113262
Received: 31 March 2021 / Revised: 24 May 2021 / Accepted: 25 May 2021 / Published: 28 May 2021
(This article belongs to the Special Issue New Trends in Polyphenols and Health)
Diabetic dyslipidemia and hyperglycemia contribute to excessive reactive oxygen species (ROS) production, leading to deleterious complications, such as nephropathy, atherosclerosis and cardiac dysfunction, and target major organs in the body. The aim of this study was to investigate the effect of caffeic acid (CA) on mouse weight and survival, serum level of fasting blood glucose (FBG), serum lipid parameters and atherogenic indices, oxidative damage in blood, liver and kidney tissue, pathophysiological changes and their function markers in healthy and alloxan-induced type 1 diabetic mice. Diabetes was induced in mice with a single intravenous injection of alloxan (75 mg kg−1). Two days later, CA (50 mg kg−1) was given intraperitoneally for seven days in diabetic mice. Diabetes affected glucose level, lipid profile, hematological and biochemical parameters, induced DNA damage and apoptotic/necrotic death in whole blood cells, liver and kidney, leading to weight loss and a decreased lifespan. CA treatment of diabetic mice revealed a protective effect on the liver and kidney, hypoglycemic and hypolipidemic properties and high protection against atherogenic outcomes. The obtained results suggest that CA is a safe and potent agent against diabetes that acts as an effective antioxidant in reducing serum glucose, lipid profile and atherogenic indices, leading to increased lifespan in mice. View Full-Text
Keywords: alloxan; diabetes; mice; caffeic acid; blood; liver and kidney damage; atherogenic indices alloxan; diabetes; mice; caffeic acid; blood; liver and kidney damage; atherogenic indices
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MDPI and ACS Style

Oršolić, N.; Sirovina, D.; Odeh, D.; Gajski, G.; Balta, V.; Šver, L.; Jazvinšćak Jembrek, M. Efficacy of Caffeic Acid on Diabetes and Its Complications in the Mouse. Molecules 2021, 26, 3262. https://doi.org/10.3390/molecules26113262

AMA Style

Oršolić N, Sirovina D, Odeh D, Gajski G, Balta V, Šver L, Jazvinšćak Jembrek M. Efficacy of Caffeic Acid on Diabetes and Its Complications in the Mouse. Molecules. 2021; 26(11):3262. https://doi.org/10.3390/molecules26113262

Chicago/Turabian Style

Oršolić, Nada, Damir Sirovina, Dyana Odeh, Goran Gajski, Vedran Balta, Lidija Šver, and Maja Jazvinšćak Jembrek. 2021. "Efficacy of Caffeic Acid on Diabetes and Its Complications in the Mouse" Molecules 26, no. 11: 3262. https://doi.org/10.3390/molecules26113262

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