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The Therapeutic Potential of Psilocybin

Biotech R & D Institute, University of the West Indies, Mona 99999, Jamaica
Vilotos Pharmaceuticals Inc., Baltimore, MD 21202, USA
Flavocure Biotech Inc., Baltimore, MD 21202, USA
Institute of Human Virology (IHV), University of Maryland School of Medicine, Baltimore, MD 21202, USA
The Psyence Group, Toronto, ON M5J 2J1, Canada
Brigham and Women’s Hospital, Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA 02215, USA
Caribbean School of Medical Sciences, Kingston 99999, Jamaica
Author to whom correspondence should be addressed.
Academic Editor: Raffaele Capasso
Molecules 2021, 26(10), 2948;
Received: 21 March 2021 / Revised: 18 April 2021 / Accepted: 22 April 2021 / Published: 15 May 2021
The psychedelic effects of some plants and fungi have been known and deliberately exploited by humans for thousands of years. Fungi, particularly mushrooms, are the principal source of naturally occurring psychedelics. The mushroom extract, psilocybin has historically been used as a psychedelic agent for religious and spiritual ceremonies, as well as a therapeutic option for neuropsychiatric conditions. Psychedelic use was largely associated with the “hippie” counterculture movement, which, in turn, resulted in a growing, and still lingering, negative stigmatization for psychedelics. As a result, in 1970, the U.S. government rescheduled psychedelics as Schedule 1 drugs, ultimately ending scientific research on psychedelics. This prohibition on psychedelic drug research significantly delayed advances in medical knowledge on the therapeutic uses of agents such as psilocybin. A 2004 pilot study from the University of California, Los Angeles, exploring the potential of psilocybin treatment in patients with advanced-stage cancer managed to reignite interest and significantly renewed efforts in psilocybin research, heralding a new age in exploration for psychedelic therapy. Since then, significant advances have been made in characterizing the chemical properties of psilocybin as well as its therapeutic uses. This review will explore the potential of psilocybin in the treatment of neuropsychiatry-related conditions, examining recent advances as well as current research. This is not a systematic review. View Full-Text
Keywords: magic mushrooms; psilocybin; psychedelic; neuropharmaceuticals; neurotherapeutics; addiction; anxiety; depression; cancer; psychopharmacology magic mushrooms; psilocybin; psychedelic; neuropharmaceuticals; neurotherapeutics; addiction; anxiety; depression; cancer; psychopharmacology
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MDPI and ACS Style

Lowe, H.; Toyang, N.; Steele, B.; Valentine, H.; Grant, J.; Ali, A.; Ngwa, W.; Gordon, L. The Therapeutic Potential of Psilocybin. Molecules 2021, 26, 2948.

AMA Style

Lowe H, Toyang N, Steele B, Valentine H, Grant J, Ali A, Ngwa W, Gordon L. The Therapeutic Potential of Psilocybin. Molecules. 2021; 26(10):2948.

Chicago/Turabian Style

Lowe, Henry, Ngeh Toyang, Blair Steele, Henkel Valentine, Justin Grant, Amza Ali, Wilfred Ngwa, and Lorenzo Gordon. 2021. "The Therapeutic Potential of Psilocybin" Molecules 26, no. 10: 2948.

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