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Review

Antimalarial Agents as Therapeutic Tools Against Toxoplasmosis—A Short Bridge between Two Distant Illnesses

1
Center of Marine Sciences, CCMAR, Gambelas Campus, University of Algarve, UAlg, 8005-139 Faro, Portugal
2
Department of Chemistry and Pharmacy, Faculty of Sciences and Technology, FCT, Gambelas Campus, University of Algarve, UAlg, 8005-139 Faro, Portugal
3
Department of Chemistry, University of Liverpool, Liverpool L69 7ZD, UK
*
Author to whom correspondence should be addressed.
These authors contributed equally to the manuscript.
Academic Editor: Branka Zorc
Molecules 2020, 25(7), 1574; https://doi.org/10.3390/molecules25071574
Received: 15 March 2020 / Revised: 26 March 2020 / Accepted: 27 March 2020 / Published: 30 March 2020
(This article belongs to the Special Issue Purposing and Repurposing of Antimalarial Agents)
Toxoplasmosis is an infectious disease with paramount impact worldwide, affecting many vulnerable populations and representing a significant matter of concern. Current therapies used against toxoplasmosis are based essentially on old chemotypes, which fail in providing a definitive cure for the disease, placing the most sensitive populations at risk for irreversible damage in vital organs, culminating in death in the most serious cases. Antimalarial drugs have been shown to possess key features for drug repurposing, finding application in the treatment of other parasite-borne illnesses, including toxoplasmosis. Antimalarials provide the most effective therapeutic solutions against toxoplasmosis and make up for the majority of currently available antitoxoplasmic drugs. Additionally, other antiplasmodial drugs have been scrutinized and many promising candidates have emanated in recent developments. Available data demonstrate that it is worthwhile to explore the activity of classical and most recent antimalarial chemotypes, such as quinolines, endoperoxides, pyrazolo[1,5-a]pyrimidines, and nature-derived peptide-based parasiticidal agents, in the context of toxoplasmosis chemotherapy, in the quest for encountering more effective and safer tools for toxoplasmosis control or eradication. View Full-Text
Keywords: Toxoplasma gondii; Plasmodium spp.; antimalarial drugs; drug repurposing; quinolines; endochin-like quinolones; endoperoxides; pyrazolo[1,5-a]pyrimidines; antimicrobial peptides Toxoplasma gondii; Plasmodium spp.; antimalarial drugs; drug repurposing; quinolines; endochin-like quinolones; endoperoxides; pyrazolo[1,5-a]pyrimidines; antimicrobial peptides
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MDPI and ACS Style

Secrieru, A.; Costa, I.C.C.; O'Neill, P.M.; Cristiano, M.L.S. Antimalarial Agents as Therapeutic Tools Against Toxoplasmosis—A Short Bridge between Two Distant Illnesses. Molecules 2020, 25, 1574. https://doi.org/10.3390/molecules25071574

AMA Style

Secrieru A, Costa ICC, O'Neill PM, Cristiano MLS. Antimalarial Agents as Therapeutic Tools Against Toxoplasmosis—A Short Bridge between Two Distant Illnesses. Molecules. 2020; 25(7):1574. https://doi.org/10.3390/molecules25071574

Chicago/Turabian Style

Secrieru, Alina, Inês C.C. Costa, Paul M. O'Neill, and Maria L.S. Cristiano 2020. "Antimalarial Agents as Therapeutic Tools Against Toxoplasmosis—A Short Bridge between Two Distant Illnesses" Molecules 25, no. 7: 1574. https://doi.org/10.3390/molecules25071574

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