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Review

Glycosylated-Chitosan Derivatives: A Systematic Review

by
Pasquale Sacco
1,
Michela Cok
1,
Francesca Scognamiglio
2,
Chiara Pizzolitto
2,
Federica Vecchies
1,
Andrea Marfoglia
1,
Eleonora Marsich
2 and
Ivan Donati
1,*
1
Department of Life Sciences, University of Trieste, Via Licio Giorgieri 5, I-34127 Trieste, Italy
2
Department of Medicine, Surgery and Health Sciences, University of Trieste, Piazza dell’Ospitale 1, I-34129 Trieste, Italy
*
Author to whom correspondence should be addressed.
Molecules 2020, 25(7), 1534; https://doi.org/10.3390/molecules25071534
Submission received: 2 March 2020 / Revised: 25 March 2020 / Accepted: 26 March 2020 / Published: 27 March 2020
(This article belongs to the Special Issue Novel Polysaccharide Materials)
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Abstract

Chitosan derivatives, and more specifically, glycosylated derivatives, are nowadays attracting much attention within the scientific community due to the fact that this set of engineered polysaccharides finds application in different sectors, spanning from food to the biomedical field. Overcoming chitosan (physical) limitations or grafting biological relevant molecules, to mention a few, represent two cardinal strategies to modify parent biopolymer; thereby, synthetizing high added value polysaccharides. The present review is focused on the introduction of oligosaccharide side chains on the backbone of chitosan. The synthetic aspects and the effect on physical-chemical properties of such modifications are discussed. Finally, examples of potential applications in biomaterials design and drug delivery of these novel modified chitosans are disclosed.
Keywords: chitosan; glycosylated-chitosan derivatives; chemical synthesis; physical-chemical properties; drug/gene delivery applications; tissue engineering applications chitosan; glycosylated-chitosan derivatives; chemical synthesis; physical-chemical properties; drug/gene delivery applications; tissue engineering applications

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MDPI and ACS Style

Sacco, P.; Cok, M.; Scognamiglio, F.; Pizzolitto, C.; Vecchies, F.; Marfoglia, A.; Marsich, E.; Donati, I. Glycosylated-Chitosan Derivatives: A Systematic Review. Molecules 2020, 25, 1534. https://doi.org/10.3390/molecules25071534

AMA Style

Sacco P, Cok M, Scognamiglio F, Pizzolitto C, Vecchies F, Marfoglia A, Marsich E, Donati I. Glycosylated-Chitosan Derivatives: A Systematic Review. Molecules. 2020; 25(7):1534. https://doi.org/10.3390/molecules25071534

Chicago/Turabian Style

Sacco, Pasquale, Michela Cok, Francesca Scognamiglio, Chiara Pizzolitto, Federica Vecchies, Andrea Marfoglia, Eleonora Marsich, and Ivan Donati. 2020. "Glycosylated-Chitosan Derivatives: A Systematic Review" Molecules 25, no. 7: 1534. https://doi.org/10.3390/molecules25071534

APA Style

Sacco, P., Cok, M., Scognamiglio, F., Pizzolitto, C., Vecchies, F., Marfoglia, A., Marsich, E., & Donati, I. (2020). Glycosylated-Chitosan Derivatives: A Systematic Review. Molecules, 25(7), 1534. https://doi.org/10.3390/molecules25071534

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