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Review

Lignans and Gut Microbiota: An Interplay Revealing Potential Health Implications

1
Department for Sustainable Food Process, Università Cattolica del Sacro Cuore, via Emilia Parmense 84, 29122 Piacenza, Italy
2
Cátedra de Fisicoquímica, Departamento de Química Analítica y Fisicoquímica, Facultad de Farmacia y Bioquímica, Universidad de Buenos Aires, Buenos Aires C1113AAD, Argentina
*
Author to whom correspondence should be addressed.
Academic Editors: Adam Jurgoński, Bartosz Fotschki and Tomasz Sawicki
Molecules 2020, 25(23), 5709; https://doi.org/10.3390/molecules25235709
Received: 12 November 2020 / Revised: 1 December 2020 / Accepted: 2 December 2020 / Published: 3 December 2020
(This article belongs to the Special Issue Plant Polyphenols and Gut Health)
Plant polyphenols are a broad group of bioactive compounds characterized by different chemical and structural properties, low bioavailability, and several in vitro biological activities. Among these compounds, lignans (a non-flavonoid polyphenolic class found in plant foods for human nutrition) have been recently studied as potential modulators of the gut–brain axis. In particular, gut bacterial metabolism is able to convert dietary lignans into therapeutically relevant polyphenols (i.e., enterolignans), such as enterolactone and enterodiol. Enterolignans are characterized by various biologic activities, including tissue-specific estrogen receptor activation, together with anti-inflammatory and apoptotic effects. However, variation in enterolignans production by the gut microbiota is strictly related to both bioaccessibility and bioavailability of lignans through the entire gastrointestinal tract. Therefore, in this review, we summarized the most important dietary source of lignans, exploring the interesting interplay between gut metabolites, gut microbiota, and the so-called gut–brain axis. View Full-Text
Keywords: phenolic compounds; bioaccessibility; enterolignans; gut microbiota; gut–brain axis phenolic compounds; bioaccessibility; enterolignans; gut microbiota; gut–brain axis
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MDPI and ACS Style

Senizza, A.; Rocchetti, G.; Mosele, J.I.; Patrone, V.; Callegari, M.L.; Morelli, L.; Lucini, L. Lignans and Gut Microbiota: An Interplay Revealing Potential Health Implications. Molecules 2020, 25, 5709. https://doi.org/10.3390/molecules25235709

AMA Style

Senizza A, Rocchetti G, Mosele JI, Patrone V, Callegari ML, Morelli L, Lucini L. Lignans and Gut Microbiota: An Interplay Revealing Potential Health Implications. Molecules. 2020; 25(23):5709. https://doi.org/10.3390/molecules25235709

Chicago/Turabian Style

Senizza, Alice, Gabriele Rocchetti, Juana I. Mosele, Vania Patrone, Maria L. Callegari, Lorenzo Morelli, and Luigi Lucini. 2020. "Lignans and Gut Microbiota: An Interplay Revealing Potential Health Implications" Molecules 25, no. 23: 5709. https://doi.org/10.3390/molecules25235709

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