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Article

Role of Daucus carota in Enhancing Antiulcer Profile of Pantoprazole in Experimental Animals

1
Department of Pharmacology, College of Pharmacy, AlMaarefa University, Riyadh 13713, Saudi Arabia
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Department of Pharmacology, Krupanidhi College of Pharmacy, Bangalore 560035, India
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College of Applied Medical Sciences, Shaqra University, Shaqra 11911, Saudi Arabia
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Clinical Pharmacy Department, King Saud Medical City, Riyadh 12746, Saudi Arabia
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Pharmaceutical Service Department, Inpatient Pharmacy, King Fahad Medical City, Riyadh 11525, Saudi Arabia
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Neonatal Intensive Care Unit, AlMoosa Specialist Hospital, Riyadh 36342, Saudi Arabia
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Department of Pharmaceutical Sciences, College of Clinical Pharmacy, King Faisal University, Al-Ahsa 31982, Saudi Arabia
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Department of Pharmaceutics, Vidya Siri College of Pharmacy, Off Sarjapura Road, Bangalore 560035, India
*
Author to whom correspondence should be addressed.
Academic Editor: Urszula Gawlik-Dziki
Molecules 2020, 25(22), 5287; https://doi.org/10.3390/molecules25225287
Received: 14 October 2020 / Revised: 30 October 2020 / Accepted: 9 November 2020 / Published: 13 November 2020
(This article belongs to the Special Issue Antioxidant Activity of Natural Compounds)
The carrot plant (Daucus carota) and its components are traditionally reported for the management of gastric ulcers. This study was performed to evaluate the role of carrot when administered concurrently with a conventional antiulcer treatment, pantoprazole, in alleviating gastric and duodenal ulcers in female experimental animals. The study involved standard animal models to determine the ulcer preventive effect using pylorus ligation, ethanol, and stress induced acute gastric ulcer models and duodenal ulcer models involving cysteamine. Acetic acid-induced chronic gastric ulcer and indomethacin-induced gastric ulcer models were used to evaluate the ulcer healing effect. Carrot fruit (500 mg/kg) and its co-administration with pantoprazole produced significant protection in an ethanol- and stress-induced acute gastric ulcer and cysteamine-induced duodenal ulcer. The healing of the acetic acid-induced chronic gastric ulcer was also augmented with this combination. Both total proteins and mucin contents were significantly increased in indomethacin-induced gastric ulcers. Similarly, in pylorus ligation, the pepsin content of gastric juice, total acidity, and free acidity were reduced. Overall, both ulcer preventive effects and ulcer healing properties of the pantoprazole were significantly enhanced in animals who received the co-administration of carrot fruit (500 mg/kg). View Full-Text
Keywords: duodenal ulcer; gastric acid; gastric cytoprotection; gastric secretion; mucin duodenal ulcer; gastric acid; gastric cytoprotection; gastric secretion; mucin
MDPI and ACS Style

Asdaq, S.M.B.; Swathi, E.; Dhamanigi, S.S.; Asad, M.; Ali Mohzari, Y.; Alrashed, A.A.; Alotaibi, A.S.; Mohammed Alhassan, B.; Nagaraja, S. Role of Daucus carota in Enhancing Antiulcer Profile of Pantoprazole in Experimental Animals. Molecules 2020, 25, 5287. https://doi.org/10.3390/molecules25225287

AMA Style

Asdaq SMB, Swathi E, Dhamanigi SS, Asad M, Ali Mohzari Y, Alrashed AA, Alotaibi AS, Mohammed Alhassan B, Nagaraja S. Role of Daucus carota in Enhancing Antiulcer Profile of Pantoprazole in Experimental Animals. Molecules. 2020; 25(22):5287. https://doi.org/10.3390/molecules25225287

Chicago/Turabian Style

Asdaq, Syed M.B., Earla Swathi, Sunil S. Dhamanigi, Mohammed Asad, Yahya Ali Mohzari, Ahmed A. Alrashed, Abdulrahman S. Alotaibi, Batool Mohammed Alhassan, and Sreeharsha Nagaraja. 2020. "Role of Daucus carota in Enhancing Antiulcer Profile of Pantoprazole in Experimental Animals" Molecules 25, no. 22: 5287. https://doi.org/10.3390/molecules25225287

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