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Molecular Targets of Cannabidiol in Experimental Models of Neurological Disease

Istituto di Ricovero e Cura a Carattere Scientifico (IRCCS) Centro Neurolesi “Bonino-Pulejo”, Via Provinciale Palermo, Contrada Casazza, 98124 Messina, Italy
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Author to whom correspondence should be addressed.
These authors contributed equally to this work.
Academic Editor: Francesca Cardona
Molecules 2020, 25(21), 5186; https://doi.org/10.3390/molecules25215186
Received: 16 October 2020 / Revised: 4 November 2020 / Accepted: 5 November 2020 / Published: 7 November 2020
(This article belongs to the Special Issue Women in Bioorganic Chemistry)
Cannabidiol (CBD) is a non-psychoactive phytocannabinoid known for its beneficial effects including antioxidant and anti-inflammatory properties. Moreover, CBD is a compound with antidepressant, anxiolytic, anticonvulsant and antipsychotic effects. Thanks to all these properties, the interest of the scientific community for it has grown. Indeed, CBD is a great candidate for the management of neurological diseases. The purpose of our review is to summarize the in vitro and in vivo studies published in the last 15 years that describe the biochemical and molecular mechanisms underlying the effects of CBD and its therapeutic application in neurological diseases. CBD exerts its neuroprotective effects through three G protein coupled-receptors (adenosine receptor subtype 2A, serotonin receptor subtype 1A and G protein-coupled receptor 55), one ligand-gated ion channel (transient receptor potential vanilloid channel-1) and one nuclear factor (peroxisome proliferator-activated receptor γ). Moreover, the therapeutical properties of CBD are also due to GABAergic modulation. In conclusion, CBD, through multi-target mechanisms, represents a valid therapeutic tool for the management of epilepsy, Alzheimer’s disease, multiple sclerosis and Parkinson’s disease. View Full-Text
Keywords: cannabidiol; molecular mechanisms; neurological diseases; neuroprotective effects cannabidiol; molecular mechanisms; neurological diseases; neuroprotective effects
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MDPI and ACS Style

Silvestro, S.; Schepici, G.; Bramanti, P.; Mazzon, E. Molecular Targets of Cannabidiol in Experimental Models of Neurological Disease. Molecules 2020, 25, 5186. https://doi.org/10.3390/molecules25215186

AMA Style

Silvestro S, Schepici G, Bramanti P, Mazzon E. Molecular Targets of Cannabidiol in Experimental Models of Neurological Disease. Molecules. 2020; 25(21):5186. https://doi.org/10.3390/molecules25215186

Chicago/Turabian Style

Silvestro, Serena; Schepici, Giovanni; Bramanti, Placido; Mazzon, Emanuela. 2020. "Molecular Targets of Cannabidiol in Experimental Models of Neurological Disease" Molecules 25, no. 21: 5186. https://doi.org/10.3390/molecules25215186

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