Next Article in Journal
Curcumin and Resveratrol Regulate Intestinal Bacteria and Alleviate Intestinal Inflammation in Weaned Piglets
Next Article in Special Issue
Using Self-Assembling Peptides to Integrate Biomolecules into Functional Supramolecular Biomaterials
Previous Article in Journal
Composition and Rheological Properties of Polysaccharide Extracted from Tamarind (Tamarindus indica L.) Seed
Previous Article in Special Issue
Engineering Peptide-Based Polyelectrolyte Complexes with Increased Hydrophobicity
Communication

Challenges in Translating from Bench to Bed-Side: Pro-Angiogenic Peptides for Ischemia Treatment

1
NangioTx Inc., Newark, NJ 07102, USA
2
Department of Gastrointestinal Surgery, Flinders Medical Centre, 5042 Bedford Park, South Australia, Australia
3
Department of Medicine Stanford School of Medicine, Stanford, CA 94305, USA
4
Department of Biomedical Engineering, Newark, NJ 07102, USA
5
Department of Chemical and Materials Engineering, New Jersey Institute of Technology, Newark, NJ 07102, USA
6
Rutgers School of Dental Medicine, Newark, NJ 07103, USA
*
Author to whom correspondence should be addressed.
Molecules 2019, 24(7), 1219; https://doi.org/10.3390/molecules24071219
Received: 9 February 2019 / Revised: 21 March 2019 / Accepted: 25 March 2019 / Published: 28 March 2019
(This article belongs to the Special Issue Recent Advances in Self-Assembled Peptides)
We describe progress and obstacles in the development of novel peptide-hydrogel therapeutics for unmet medical needs in ischemia treatment, focusing on the development and translation of therapies specifically in peripheral artery disease (PAD). Ischemia is a potentially life-threatening complication in PAD, which affects a significant percentage of the elderly population. While studies on inducing angiogenesis to treat PAD were started two decades ago, early results from animal models as well as clinical trials have not yet been translated into clinical practice. We examine some of the challenges encountered during such translation. We further note the need for sustained angiogenic effect involving whole growth factor, gene therapy and synthetic growth factor strategies. Finally, we discuss the need for tissue depots for de novo formation of microvasculature. These scaffolds can act as templates for neovasculature development to improve circulation and healing at the preferred anatomical location. View Full-Text
Keywords: angiogenesis; peptide; translation; ischemia; therapeutic; development angiogenesis; peptide; translation; ischemia; therapeutic; development
MDPI and ACS Style

Petrak, K.; Vissapragada, R.; Shi, S.; Siddiqui, Z.; Kim, K.K.; Sarkar, B.; Kumar, V.A. Challenges in Translating from Bench to Bed-Side: Pro-Angiogenic Peptides for Ischemia Treatment. Molecules 2019, 24, 1219. https://doi.org/10.3390/molecules24071219

AMA Style

Petrak K, Vissapragada R, Shi S, Siddiqui Z, Kim KK, Sarkar B, Kumar VA. Challenges in Translating from Bench to Bed-Side: Pro-Angiogenic Peptides for Ischemia Treatment. Molecules. 2019; 24(7):1219. https://doi.org/10.3390/molecules24071219

Chicago/Turabian Style

Petrak, Karel, Ravi Vissapragada, Siyu Shi, Zain Siddiqui, Ka K. Kim, Biplab Sarkar, and Vivek A. Kumar. 2019. "Challenges in Translating from Bench to Bed-Side: Pro-Angiogenic Peptides for Ischemia Treatment" Molecules 24, no. 7: 1219. https://doi.org/10.3390/molecules24071219

Find Other Styles
Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Article Access Map by Country/Region

1
Back to TopTop