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Open AccessFeature PaperCommunication
Molecules 2019, 24(3), 601; https://doi.org/10.3390/molecules24030601

One-Pot Synthesis of Triazolobenzodiazepines Through Decarboxylative [3 + 2] Cycloaddition of Nonstabilized Azomethine Ylides and Cu-Free Click Reactions

1
School of Pharmaceutical Engineering and Life Science, Changzhou University, Changzhou 213164, China
2
Department of Chemistry, University of Massachusetts Boston, 100 Morrissey Boulevard, Boston, MA 02125, USA
3
School of Science, Jiaozuo Teachers’ College, 998 Shanyang Road, Jiaozuo 454100, China
*
Author to whom correspondence should be addressed.
These authors contributed equally to this work.
Received: 16 January 2019 / Revised: 3 February 2019 / Accepted: 5 February 2019 / Published: 8 February 2019
(This article belongs to the Special Issue Sustainable Synthesis)
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Abstract

A one-pot synthesis of triazolobenzodiazepine-containing polycyclic compounds is introduced. The reaction process involves a decarboxylative three-component [3 + 2] cycloaddition of nonstabilized azomethine ylides, N-propargylation, and intramolecular click reactions. View Full-Text
Keywords: one-pot synthesis; decarboxylative [3 + 2] cycloaddition; nonstabilized azomethine ylides; click reaction one-pot synthesis; decarboxylative [3 + 2] cycloaddition; nonstabilized azomethine ylides; click reaction
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited (CC BY 4.0).

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Ma, X.; Zhang, X.; Qiu, W.; Zhang, W.; Wan, B.; Evans, J.; Zhang, W. One-Pot Synthesis of Triazolobenzodiazepines Through Decarboxylative [3 + 2] Cycloaddition of Nonstabilized Azomethine Ylides and Cu-Free Click Reactions. Molecules 2019, 24, 601.

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