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Article

Cytotoxic Polyketides from a Deep-Sea Sediment Derived Fungus Diaporthe phaseolorum FS431

by
Zheng Niu
,
Yuchan Chen
,
Heng Guo
,
Sai-Ni Li
,
Hao-Hua Li
,
Hong-Xin Liu
,
Zhaoming Liu
* and
Weimin Zhang
*
State Key Laboratory of Applied Microbiology Southern China, Guangdong Provincial Key Laboratory of Microbial Culture Collection and Application, Guangdong Open Laboratory of Applied Microbiology, Guangdong Institute of Microbiology, Guangdong Academy of Sciences, Yuexiu District, Guangzhou 510070, China
*
Authors to whom correspondence should be addressed.
Molecules 2019, 24(17), 3062; https://doi.org/10.3390/molecules24173062
Submission received: 22 July 2019 / Revised: 20 August 2019 / Accepted: 21 August 2019 / Published: 22 August 2019
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Abstract

Two new chromone-derived polyketides phaseolorins, G and H (1 and 2), and one new anthraquinone derivative, phaseolorin I (3), together with three known compounds (4–6), were isolated from the deep-sea sediment-derived fungus Diaporthe phaseolorum FS431. The structures of the new compounds were determined by comprehensive analysis of their spectroscopic data, and the absolute configuration of 1 was established by quantum chemical calculations of electron capture detection (ECD). All the isolated compounds (1–6) were tested for their in vitro cytotoxic activities against four human tumor cell lines, of which compound 4 exhibited significant effect against MCF-7, HepG-2, and A549 tumor cell lines with IC50 values of 2.60, 2.55, and 4.64 µM, respectively.
Keywords: Diaporthe phaseolorum; deep-sea derived fungus; polyketides; cytotoxicity Diaporthe phaseolorum; deep-sea derived fungus; polyketides; cytotoxicity

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MDPI and ACS Style

Niu, Z.; Chen, Y.; Guo, H.; Li, S.-N.; Li, H.-H.; Liu, H.-X.; Liu, Z.; Zhang, W. Cytotoxic Polyketides from a Deep-Sea Sediment Derived Fungus Diaporthe phaseolorum FS431. Molecules 2019, 24, 3062. https://doi.org/10.3390/molecules24173062

AMA Style

Niu Z, Chen Y, Guo H, Li S-N, Li H-H, Liu H-X, Liu Z, Zhang W. Cytotoxic Polyketides from a Deep-Sea Sediment Derived Fungus Diaporthe phaseolorum FS431. Molecules. 2019; 24(17):3062. https://doi.org/10.3390/molecules24173062

Chicago/Turabian Style

Niu, Zheng, Yuchan Chen, Heng Guo, Sai-Ni Li, Hao-Hua Li, Hong-Xin Liu, Zhaoming Liu, and Weimin Zhang. 2019. "Cytotoxic Polyketides from a Deep-Sea Sediment Derived Fungus Diaporthe phaseolorum FS431" Molecules 24, no. 17: 3062. https://doi.org/10.3390/molecules24173062

APA Style

Niu, Z., Chen, Y., Guo, H., Li, S.-N., Li, H.-H., Liu, H.-X., Liu, Z., & Zhang, W. (2019). Cytotoxic Polyketides from a Deep-Sea Sediment Derived Fungus Diaporthe phaseolorum FS431. Molecules, 24(17), 3062. https://doi.org/10.3390/molecules24173062

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