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Molecules 2019, 24(1), 187;

Triterpenoids from Cyclocarya paliurus that Enhance Glucose Uptake in 3T3-L1 Adipocytes

College of Pharmaceutical Sciences, Zhejiang University, 866 Yuhangtang Road, Hangzhou 310058, China
State Key Laboratory of Quality Research in Chinese Medicine, Institute of Chinese Medical Sciences, University of Macau, Macao 999078, China
Hangzhou Institute of Innovative Medicine, Zhejiang University, 291 Fucheng Road, Hangzhou 310018, China
These authors contributed equally to this work.
Authors to whom correspondence should be addressed.
Received: 8 December 2018 / Revised: 26 December 2018 / Accepted: 30 December 2018 / Published: 6 January 2019
(This article belongs to the Special Issue Natural Products in Prevention and Treatment of Metabolic Syndrome)
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Four previously undescribed compounds, including three rarely occurring seco-dammarane triterpenoid glycosides and a pentacyclic triterpenic acid, were isolated from a 70% ethanol extract of the leaves of Cyclocarya paliurus (Juglandaceae), along with eleven known triterpenoids. Their structures were determined by spectroscopic techniques, including 2D NMR and HRESIMS, as well as chemical methods. Among them, several triterpenoids enhanced insulin stimulated glucose uptake in both 3T3-L1 adipocytes and C2C12 myotubes. Furthermore, compound 1 dose-dependently increased glucose uptake through activating AMP-activated protein kinase (AMPK)-p38 pathway. Collectively, triterpenoids from C. paliurus could be developed as insulin sensitizers, which might have therapeutic potential for insulin resistance and hyperglycemia. View Full-Text
Keywords: Cyclocarya paliurus (Juglandaceae); seco-dammarane triterpenoids; glucose uptake; adipocytes Cyclocarya paliurus (Juglandaceae); seco-dammarane triterpenoids; glucose uptake; adipocytes

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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited (CC BY 4.0).

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Fang, Z.-J.; Shen, S.-N.; Wang, J.-M.; Wu, Y.-J.; Zhou, C.-X.; Mo, J.-X.; Lin, L.-G.; Gan, L.-S. Triterpenoids from Cyclocarya paliurus that Enhance Glucose Uptake in 3T3-L1 Adipocytes. Molecules 2019, 24, 187.

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