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Molecules 2018, 23(4), 887;

Three New Polyynes from Codonopsis pilosula and Their Activities on Lipid Metabolism

1,* and 2,4,5,*
School of Pharmacy and Chemistry, Dali University, Dali 671000, China
Guangdong Key Laboratory for Genome Stability & Disease Prevention, School of Pharmaceutical Sciences, School of Medicine, Shenzhen University Health Science Center, Shenzhen 518060, China
State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650201, China
School of Pharmacy, Henan University of Chinese Medicine, Zhengzhou 450008, China
College of Pharmacy, Chengdu University of Traditional Chinese Medicine, Chengdu 610075, China
These authors contributed equally to this work.
Authors to whom correspondence should be addressed.
Received: 14 March 2018 / Revised: 27 March 2018 / Accepted: 27 March 2018 / Published: 12 April 2018
(This article belongs to the Section Natural Products Chemistry)
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Three new polyynes, named choushenpilosulynes A–C (13), were isolated from an 85% aqueous EtOH extract of the roots of Codonopsis pilosula cultivated in Xundian County of Yunnan province, China. Their structures, including the absolute configuration of the glucose residue in 1 and 2, were determined by spectroscopic analysis and gas chromatography (GC). In addition, biological evaluation shows that all the compounds can inhibit the expression of the squalene monooxygenase (SQLE) gene in HepG2 cells, suggesting that these compounds may be involved in lipid metabolism. View Full-Text
Keywords: Codonopsis pilosula; choushenpilosulynes A–C; lipid metabolism Codonopsis pilosula; choushenpilosulynes A–C; lipid metabolism

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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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Hu, X.-Y.; Qin, F.-Y.; Lu, X.-F.; Zhang, L.-S.; Cheng, Y.-X. Three New Polyynes from Codonopsis pilosula and Their Activities on Lipid Metabolism. Molecules 2018, 23, 887.

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