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Open AccessArticle

Steroidal Constituents from Roots and Rhizomes of Smilacina japonica

1
Institute of Materia Medica, School of Pharmacy, Fourth Military Medical University, Xi’an 710032, China
2
Department of Pharmacy, Xi’an Medical University, Xi’an 710021, China
3
Shaanxi Collaborative Innovation Center of Chinese Medicinal Resource Industrialization, Laboratory of New Drugs and Chinese Medicine Foundation Research, Shaanxi Rheumatism and Tumor Center of TCM Engineering Technology Research, School of Pharmacy, Shaanxi University of Chinese Medicine, Xianyang 712046, China
4
The College of Pharmacy, Shanghai University of Traditional Chinese Medicine, Shanghai 200001, China
5
The College of Life Sciences, Northwest University, Xi’an 710069, China
*
Author to whom correspondence should be addressed.
The authors contribute equally to this work.
Molecules 2018, 23(4), 798; https://doi.org/10.3390/molecules23040798
Received: 6 March 2018 / Revised: 27 March 2018 / Accepted: 28 March 2018 / Published: 30 March 2018
Four new steroidal constituents (14) along with two known steroidal glycosides (5 and 6) were isolated from the roots and rhizomes of Smilacina japonica. Analysis of their physicochemical properties and spectroscopic profiles identified the compounds as (25S)-5α-spirostan-9(11)-en-3β, 17α-diol (1); (25S)-5α-spirostan-9(11)-en-3β, 12β-diol (2); (25S)-5α-spirostan-9(11)-en-3β, 17α-diol-3-O-β-d-glucopyranoside (3); (25S)-5α-spirostan-9(11)-en-3β, 17α-diol-3-O-β-d-glucopyranosyl-(1→2)-[β-d-glucopyranosyl-(1→3)]-β-d-galactopyranoside (4); japonicoside B (5); and japonicoside C (6). All six compounds showed cytotoxic activity against SMMC-7712, Bel-7402, A549, H460, and K562 human cancer cells. View Full-Text
Keywords: Smilacina japonica; steroidal constituents; structure identification; cytotoxicity Smilacina japonica; steroidal constituents; structure identification; cytotoxicity
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MDPI and ACS Style

Cui, Y.; Yang, X.; Zhang, D.; Li, Y.; Zhang, L.; Song, B.; Yue, Z.; Song, X.; Tang, H. Steroidal Constituents from Roots and Rhizomes of Smilacina japonica. Molecules 2018, 23, 798.

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