Potential Anti-Inflammatory and Anti-Cancer Properties of Farnesol
AbstractFarnesol, an acyclic sesquiterpene alcohol, is predominantly found in essential oils of various plants in nature. It has been reported to exhibit anti-cancer and anti-inflammatory effects, and also alleviate allergic asthma, gliosis, and edema. In numerous tumor cell lines, farnesol can modulate various tumorigenic proteins and/or modulates diverse signal transduction cascades. It can also induce apoptosis and downregulate cell proliferation, angiogenesis, and cell survival. To exert its anti-inflammatory/anti-oncogenic effects, farnesol can modulate Ras protein and nuclear factor kappa-light-chain-enhancer of activated B cells activation to downregulate the expression of various inflammatory mediators such as cyclooxygenase-2, inducible nitric oxide synthase, tumor necrosis factor alpha, and interleukin-6. In this review, we describe the potential mechanisms of action underlying the therapeutic effects of farnesol against cancers and inflammatory disorders. Furthermore, these findings support the clinical development of farnesol as a potential pharmacological agent in clinical studies. View Full-Text
Share & Cite This Article
Jung, Y.Y.; Hwang, S.T.; Sethi, G.; Fan, L.; Arfuso, F.; Ahn, K.S. Potential Anti-Inflammatory and Anti-Cancer Properties of Farnesol. Molecules 2018, 23, 2827.
Jung YY, Hwang ST, Sethi G, Fan L, Arfuso F, Ahn KS. Potential Anti-Inflammatory and Anti-Cancer Properties of Farnesol. Molecules. 2018; 23(11):2827.Chicago/Turabian Style
Jung, Young Y.; Hwang, Sun T.; Sethi, Gautam; Fan, Lu; Arfuso, Frank; Ahn, Kwang S. 2018. "Potential Anti-Inflammatory and Anti-Cancer Properties of Farnesol." Molecules 23, no. 11: 2827.
Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.