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Open AccessFeature PaperReview

Potential Anti-Inflammatory and Anti-Cancer Properties of Farnesol

Department of Science in Korean Medicine, Kyung Hee University, 24 Kyungheedae-ro, Dongdaemun-gu, Seoul 02447, Korea
Department of Pharmacology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore 117600, Singapore
Stem Cell and Cancer Biology Laboratory, School of Pharmacy and Biomedical Sciences, Curtin Health Innovation Research Institute, Curtin University, Perth WA 6009, Australia
Department of Korean Pathology, College of Korean Medicine, Kyung Hee University, 24 Kyungheedae-ro, Dongdaemun-gu, Seoul 02447, Korea
Authors to whom correspondence should be addressed.
These authors contributed equally to this work.
Molecules 2018, 23(11), 2827;
Received: 5 October 2018 / Revised: 23 October 2018 / Accepted: 30 October 2018 / Published: 31 October 2018
(This article belongs to the Collection Natural Products: Anticancer Potential and Beyond)
Farnesol, an acyclic sesquiterpene alcohol, is predominantly found in essential oils of various plants in nature. It has been reported to exhibit anti-cancer and anti-inflammatory effects, and also alleviate allergic asthma, gliosis, and edema. In numerous tumor cell lines, farnesol can modulate various tumorigenic proteins and/or modulates diverse signal transduction cascades. It can also induce apoptosis and downregulate cell proliferation, angiogenesis, and cell survival. To exert its anti-inflammatory/anti-oncogenic effects, farnesol can modulate Ras protein and nuclear factor kappa-light-chain-enhancer of activated B cells activation to downregulate the expression of various inflammatory mediators such as cyclooxygenase-2, inducible nitric oxide synthase, tumor necrosis factor alpha, and interleukin-6. In this review, we describe the potential mechanisms of action underlying the therapeutic effects of farnesol against cancers and inflammatory disorders. Furthermore, these findings support the clinical development of farnesol as a potential pharmacological agent in clinical studies. View Full-Text
Keywords: farnesol; inflammation; cancer; apoptosis farnesol; inflammation; cancer; apoptosis
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MDPI and ACS Style

Jung, Y.Y.; Hwang, S.T.; Sethi, G.; Fan, L.; Arfuso, F.; Ahn, K.S. Potential Anti-Inflammatory and Anti-Cancer Properties of Farnesol. Molecules 2018, 23, 2827.

AMA Style

Jung YY, Hwang ST, Sethi G, Fan L, Arfuso F, Ahn KS. Potential Anti-Inflammatory and Anti-Cancer Properties of Farnesol. Molecules. 2018; 23(11):2827.

Chicago/Turabian Style

Jung, Young Y.; Hwang, Sun T.; Sethi, Gautam; Fan, Lu; Arfuso, Frank; Ahn, Kwang S. 2018. "Potential Anti-Inflammatory and Anti-Cancer Properties of Farnesol" Molecules 23, no. 11: 2827.

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