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Synthesis of Europium-Doped Fluorapatite Nanorods and Their Biomedical Applications in Drug Delivery

Department of Plastic Surgery, Zhejiang Provincial People’s Hospital, People’s Hospital of Hangzhou Medical College, Hangzhou 310014, China
State Key Laboratory of Oral Diseases, West China Hospital of Stomatology, Sichuan University, Chengdu 610041, China
Department of Biomedical Engineering, College of Engineering, Peking University, Beijing 100871, China
Authors to whom correspondence should be addressed.
Academic Editor: Svetlana V. Eliseeva
Molecules 2017, 22(5), 753;
Received: 5 April 2017 / Revised: 23 April 2017 / Accepted: 4 May 2017 / Published: 6 May 2017
(This article belongs to the Special Issue Lanthanide Luminescence: Fundamental Research and Applications)
Europium (Eu)-doped fluorapatite (FA) nanorods have a biocompatibility similar to that of hydroxyapatite (HA) for use as cell imaging biomaterials due to their luminescent property. Here, we discuss the new application of europium-doped fluorapatite (Eu-FA) nanorods as an anticancer drug carrier. The Eu-FA nanorods were prepared by using a hydrothermal method. The morphology, crystal structure, fluorescence, and composition were investigated. The specific crystal structure enables the effective loading of drug molecules. Doxorubicin (DOX), which was used as a model anticancer drug, effectively loaded onto the surface of the nanorods. The DOX release was pH-dependent and occurred more rapidly at pH 5.5 than at pH 7.4. The intracellular penetration of the DOX-loaded Eu-FA nanorods (Eu-FA/DOX) can be imaged in situ due to the self-fluorescence property. Treatment of melanoma A375 cells with Eu-FA/DOX elicited a more effective apoptosis rate than direct DOX treatment. Overall, Eu-FA exhibits potential for tracking and treating tumors and may be potentially useful as a multifunctional carrier system to effectively load and sustainably deliver drugs. View Full-Text
Keywords: lanthanides; fluorapatite; drug loading; nano carrier lanthanides; fluorapatite; drug loading; nano carrier
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MDPI and ACS Style

Zeng, H.; Li, X.; Sun, M.; Wu, S.; Chen, H. Synthesis of Europium-Doped Fluorapatite Nanorods and Their Biomedical Applications in Drug Delivery. Molecules 2017, 22, 753.

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