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Acetylcholinesterase Inhibitory Meroterpenoid from a Mangrove Endophytic Fungus Aspergillus sp. 16-5c

School of Chemistry, Sun Yat-Sen University, Guangzhou 510275, China
School of Chemistry and Environment, South China Normal University, Guangzhou 510006, China
The Sixth Affiliated Hospital of Sun Yat-sen University, Guangzhou 510275, China
Author to whom correspondence should be addressed.
Academic Editor: Maria G. Miguel
Molecules 2017, 22(5), 727;
Received: 12 April 2017 / Revised: 26 April 2017 / Accepted: 28 April 2017 / Published: 3 May 2017
PDF [2213 KB, uploaded 3 May 2017]


One new meroterpenoid, named 2-hydroacetoxydehydroaustin (1), together with nine known meroterpenoids, 11-acetoxyisoaustinone (2), isoaustinol (3), austin (4), austinol (5), acetoxydehydroaustin (6), dehydroaustin (7), dehydroaustinol (8), preaustinoid A2 (9), and 1,2-dihydro-acetoxydehydroaustin B (10), were isolated from the mangrove endophytic fungus, Aspergillus sp. 16-5c. These structures were characterized by spectroscopic analysis, further the absolute configurations of stereogenic carbons for Compounds 1, 3, 4, 6, 7, 8, 9, and 10 were determined by single crystal X-ray diffraction analysis using Cu Kα radiation. Moreover, the absolute configurations of stereogenic carbons for Known Compounds 3, 7, 8, and 9 are identified here for the first time. Compounds 3, 7, and 8 showed acetylcholinesterase (AchE) inhibitory activity with IC50 values of 2.50, 0.40, and 3.00 μM, respectively. View Full-Text
Keywords: meroterpenoids; Aspergillus sp.; acetylcholinesterase (AchE) inhibitory meroterpenoids; Aspergillus sp.; acetylcholinesterase (AchE) inhibitory

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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited (CC BY 4.0).

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Long, Y.; Cui, H.; Liu, X.; Xiao, Z.; Wen, S.; She, Z.; Huang, X. Acetylcholinesterase Inhibitory Meroterpenoid from a Mangrove Endophytic Fungus Aspergillus sp. 16-5c. Molecules 2017, 22, 727.

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