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Open AccessArticle

Acetylcholinesterase Inhibitory Meroterpenoid from a Mangrove Endophytic Fungus Aspergillus sp. 16-5c

1
School of Chemistry, Sun Yat-Sen University, Guangzhou 510275, China
2
School of Chemistry and Environment, South China Normal University, Guangzhou 510006, China
3
The Sixth Affiliated Hospital of Sun Yat-sen University, Guangzhou 510275, China
*
Author to whom correspondence should be addressed.
Academic Editor: Maria G. Miguel
Molecules 2017, 22(5), 727; https://doi.org/10.3390/molecules22050727
Received: 12 April 2017 / Revised: 26 April 2017 / Accepted: 28 April 2017 / Published: 3 May 2017
One new meroterpenoid, named 2-hydroacetoxydehydroaustin (1), together with nine known meroterpenoids, 11-acetoxyisoaustinone (2), isoaustinol (3), austin (4), austinol (5), acetoxydehydroaustin (6), dehydroaustin (7), dehydroaustinol (8), preaustinoid A2 (9), and 1,2-dihydro-acetoxydehydroaustin B (10), were isolated from the mangrove endophytic fungus, Aspergillus sp. 16-5c. These structures were characterized by spectroscopic analysis, further the absolute configurations of stereogenic carbons for Compounds 1, 3, 4, 6, 7, 8, 9, and 10 were determined by single crystal X-ray diffraction analysis using Cu Kα radiation. Moreover, the absolute configurations of stereogenic carbons for Known Compounds 3, 7, 8, and 9 are identified here for the first time. Compounds 3, 7, and 8 showed acetylcholinesterase (AchE) inhibitory activity with IC50 values of 2.50, 0.40, and 3.00 μM, respectively. View Full-Text
Keywords: meroterpenoids; Aspergillus sp.; acetylcholinesterase (AchE) inhibitory meroterpenoids; Aspergillus sp.; acetylcholinesterase (AchE) inhibitory
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MDPI and ACS Style

Long, Y.; Cui, H.; Liu, X.; Xiao, Z.; Wen, S.; She, Z.; Huang, X. Acetylcholinesterase Inhibitory Meroterpenoid from a Mangrove Endophytic Fungus Aspergillus sp. 16-5c. Molecules 2017, 22, 727.

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