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Molecules 2017, 22(5), 683;

Xanthones from the Pericarp of Garcinia mangostana

Key Laboratory of Tropical Agro Environment, Ministry of Agriculture and Guangdong Engineering Research Centre for Modern Eco-Agriculture, South China Agricultural University, Guangzhou 510642, China
Department of Neurobiology, School of Basic Medical Sciences, Southern Medical University, Guangzhou 510515, China
Laboratory of State Administration of Traditional Chinese Medicine for Production and Development of Cantonese Medicinal Materials, School of Chinese Materia Medica, Guangdong Pharmaceutical University, Guangzhou 510006, China
These authors contributed equally to this work.
Authors to whom correspondence should be addressed.
Academic Editor: Derek J. McPhee
Received: 20 March 2017 / Revised: 17 April 2017 / Accepted: 18 April 2017 / Published: 25 April 2017
(This article belongs to the Section Natural Products Chemistry)
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Mangosteen (Garcinia mangostana L.) is one of the most popular tropical fruits (called the “Queen of Fruits”), and is a rich source of oxygenated and prenylated xanthone derivatives. In the present work, phytochemical investigation has resulted in one new prenylated xanthone and 13 known xanthones isolated from the pericarp of G. mangostana. Their structures were established by spectroscopic data analysis, including X-ray diffraction. The new one was further tested for cytotoxic activity against seven cancer cell lines (CNE-1, CNE-2, A549, H490, PC-3, SGC-7901, U87), displaying the half maximal inhibitory concentration (IC50) values 3.35, 4.01, 4.84, 7.84, 6.21, 8.09, and 6.39 μM, respectively. It is noteworthy that the new compound can promote CNE-2 cells apoptosis in late stage, having a remarkable inhibition effect on the side population growth of CNE-2 at 1.26 μM. The bioactive compound was also detected in extract from fresh mangosteen flesh, which indicated that the popular fruit could have potential cytotoxic activity for cancer cell lines. View Full-Text
Keywords: Garcinia mangostana; xanthone; cell lines; cytotoxic Garcinia mangostana; xanthone; cell lines; cytotoxic

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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited (CC BY 4.0).

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Yang, R.; Li, P.; Li, N.; Zhang, Q.; Bai, X.; Wang, L.; Xiao, Y.; Sun, L.; Yang, Q.; Yan, J. Xanthones from the Pericarp of Garcinia mangostana. Molecules 2017, 22, 683.

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