Xanthones from the Pericarp of Garcinia mangostana
Abstract
:1. Introduction
2. Results and Discussion
3. Materials and Methods
3.1. General Experimental Procedures
3.2. Plant Material
3.3. Sample Preparation and Isolation
3.4. Cell Culture
3.5. MTT Assay
3.6. FCM Assay
4. Conclusions
Supplementary Materials
Acknowledgments
Author Contributions
Conflicts of Interest
References
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Sample Availability: Samples of the compounds are available from the authors. |
Position | Compound 1 | |
---|---|---|
13C | 1H | |
1 | 157.1 | |
2 | 103.6 | |
3 | 158.4 | |
4 | 93.6 | 6.32, s |
4a | 155.6 | |
5 | 100.1 | 6.76, s |
6 | 152.8 | |
7 | 141.2 | |
8 | 127.6 | |
8a | 109.6 | |
9 | 181.7 | |
9a | 102.9 | |
10a | 152.0 | |
11 | 114.8 | 6.61, d, 9.9 |
12 | 128.0 | 5.73, d, 9.9 |
13 | 77.9 | |
14 | 27.4 | 1.43, s |
15 | 27.4 | 1.43, s |
16 | 25.3 | 4.02, d, 6.8 |
17 | 123.5 | 5.18, t, 6.8 |
18 | 130.2 | |
19 | 25.7 | 1.61, s |
20 | 18.3 | 1.78, s |
Concentration (μM) | Cell Lines | |||||||
---|---|---|---|---|---|---|---|---|
CNE-1 | CNE-2 | A549 | H460 | PC-3 | SGC-7901 | U87 | PC12 | |
0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
0.40 | 0 | 5.4 | 10.6 | 0 | 7.27 | 1.94 | 0 | / |
0.81 | 4.35 | 12.87 | 11.11 | 0 | 10.08 | 3.37 | 14.26 | / |
1.58 | 47.42 | 15.96 | 23.81 | 1.15 | 12.27 | 17.98 | 16.25 | / |
3.17 | 63.68 | 51.92 | 49.6 | 20.04 | 32.93 | 47.7 | 26.55 | 2.19 |
6.34 | 69.4 | 71.24 | 62.54 | 50.72 | 58.68 | 49.17 | 49.15 | 11.33 |
12.69 | 78.42 | 80.01 | 63.18 | 58.45 | 64.59 | 51.74 | 68.24 | 4.66 |
25.3 | 83.9 | 83.89 | 73.98 | 84.86 | 72.64 | 54.91 | 72.56 | 23.82 |
50.7 | / | / | / | / | / | / | / | 40.57 |
101.5 | / | / | / | / | / | / | / | 58.21 |
IC50 | 3.35 | 4.01 | 4.84 | 7.84 | 6.21 | 8.09 | 6.39 | >50 |
(2.51 μg/mL) | (19.7 μg/mL) |
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Share and Cite
Yang, R.; Li, P.; Li, N.; Zhang, Q.; Bai, X.; Wang, L.; Xiao, Y.; Sun, L.; Yang, Q.; Yan, J. Xanthones from the Pericarp of Garcinia mangostana. Molecules 2017, 22, 683. https://doi.org/10.3390/molecules22050683
Yang R, Li P, Li N, Zhang Q, Bai X, Wang L, Xiao Y, Sun L, Yang Q, Yan J. Xanthones from the Pericarp of Garcinia mangostana. Molecules. 2017; 22(5):683. https://doi.org/10.3390/molecules22050683
Chicago/Turabian StyleYang, Renyue, Ping Li, Nana Li, Qian Zhang, Xue Bai, Lishuo Wang, Yiying Xiao, Lirong Sun, Quan Yang, and Jian Yan. 2017. "Xanthones from the Pericarp of Garcinia mangostana" Molecules 22, no. 5: 683. https://doi.org/10.3390/molecules22050683