New Cassane Diterpenoids from Caesalpinia sappan and their Antiplasmodial Activity
Key Laboratory of Bioactive Substances and Resource Utilization of Chinese Herbal Medicine, Ministry of Education, Beijing Key Laboratory of Innovative Drug Discovery of Traditional Chinese Medicine (Natural Medicine) and Translational Medicine, Key Laboratory of Efficacy Evaluation of Chinese Medicine against Glycolipid Metabolic Disorders, State Administration of Traditional Chinese Medicine, Institute of Medicinal Plant Development, Peking Union Medical College and Chinese Academy of Medical Sciences, Beijing 100193, China
Center of Research and Development on Life Sciences and Environment Sciences, Harbin University of Commerce, Harbin 150076, China
College of chemistry and materials science, Guangxi Teachers Education University, Nanning 530001, China
These authors contributed equally to this work.
Authors to whom correspondence should be addressed.
Received: 24 August 2017 / Revised: 13 October 2017 / Accepted: 13 October 2017 / Published: 17 October 2017
One new cassane diterpene possessing an unusual N
bridge between C-19 and C-20 named caesalsappanin R (1
), as well as another new diterpene caesalsappanin S (2
), were isolated from the seeds of Caesalpinia sappan
with methanol extract. Their structures were determined by spectroscopic analysis and examined alongside existing data from prior studies. Their biological activities were profiled by their antiplasmodial activity.
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Zhu, N.-L.; Sun, Z.-H.; Hu, M.-G.; Wu, T.-Y.; Yuan, J.-Q.; Wu, H.-F.; Tian, Y.; Li, P.-F.; Yang, J.-S.; Ma, G.-X.; Xu, X.-D. New Cassane Diterpenoids from Caesalpinia sappan and their Antiplasmodial Activity. Molecules 2017, 22, 1751.
Zhu N-L, Sun Z-H, Hu M-G, Wu T-Y, Yuan J-Q, Wu H-F, Tian Y, Li P-F, Yang J-S, Ma G-X, Xu X-D. New Cassane Diterpenoids from Caesalpinia sappan and their Antiplasmodial Activity. Molecules. 2017; 22(10):1751.
Zhu, Nai-Liang; Sun, Zhong-Hao; Hu, Mei-Geng; Wu, Tong-Yu; Yuan, Jing-Quan; Wu, Hai-Feng; Tian, Yu; Li, Peng-Fei; Yang, Jun-Shan; Ma, Guo-Xu; Xu, Xu-Dong. 2017. "New Cassane Diterpenoids from Caesalpinia sappan and their Antiplasmodial Activity." Molecules 22, no. 10: 1751.
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