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Molecules 2017, 22(10), 1582;

N-Halamine Biocidal Materials with Superior Antimicrobial Efficacies for Wound Dressings

Department of Chemistry and Biochemistry, Auburn University, Auburn, AL 36849, USA
Center for Polymers and Advanced Composites, Department of Mechanical Engineering, Auburn University, Auburn, AL 36849, USA
Department of Poultry Science, Auburn University, Auburn, AL 36849, USA
Author to whom correspondence should be addressed.
Received: 21 August 2017 / Revised: 18 September 2017 / Accepted: 20 September 2017 / Published: 21 September 2017
(This article belongs to the Special Issue Antibacterial Materials and Coatings)
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This work demonstrated the successful application of N-halamine technology for wound dressings rendered antimicrobial by facile and inexpensive processes. Four N-halamine compounds, which possess different functional groups and chemistry, were synthesized. The N-halamine compounds, which contained oxidative chlorine, the source of antimicrobial activity, were impregnated into or coated onto standard non-antimicrobial wound dressings. N-halamine-employed wound dressings inactivated about 6 to 7 logs of Staphylococcus aureus and Pseudomonas aeruginosa bacteria in brief periods of contact time. Moreover, the N-halamine-modified wound dressings showed superior antimicrobial efficacies when compared to commercially available silver wound dressings. Zone of inhibition tests revealed that there was no significant leaching of the oxidative chlorine from the materials, and inactivation of bacteria occurred by direct contact. Shelf life stability tests showed that the dressings were stable to loss of oxidative chlorine when they were stored for 6 months in dark environmental conditions. They also remained stable under florescent lighting for up to 2 months of storage. They could be stored in opaque packaging to improve their shelf life stabilities. In vitro skin irritation testing was performed using a three-dimensional human reconstructed tissue model (EpiDerm™). No potential skin irritation was observed. In vitro cytocompatibility was also evaluated. These results indicate that N-halamine wound dressings potentially can be employed to prevent infections, while at the same time improving the healing process by eliminating undesired bacterial growth. View Full-Text
Keywords: N-halamine; antimicrobial efficacies; medical wound dressings; antibacterial materials N-halamine; antimicrobial efficacies; medical wound dressings; antibacterial materials

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Demir, B.; Broughton, R.M.; Qiao, M.; Huang, T.-S.; Worley, S.D. N-Halamine Biocidal Materials with Superior Antimicrobial Efficacies for Wound Dressings. Molecules 2017, 22, 1582.

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