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Open AccessReview

Synthetic Strategies for Peroxide Ring Construction in Artemisinin

N. D. Zelinsky Institute of Organic Chemistry, Russian Academy of Sciences, 47 Leninsky Prospekt, Moscow 119991, Russia
Faculty of Chemical and Pharmaceutical Technology and Biomedical Products, D. I. Mendeleev University of Chemical Technology of Russia, 9 Miusskaya Square, Moscow 125047, Russia
All-Russian Research Institute for Phytopathology, 143050 B. Vyazyomy, Moscow Region, Russia
Author to whom correspondence should be addressed.
Academic Editor: Svetlana B. Tsogoeva
Molecules 2017, 22(1), 117;
Received: 25 December 2016 / Revised: 7 January 2017 / Accepted: 9 January 2017 / Published: 11 January 2017
(This article belongs to the Special Issue Artemisinin: Against Malaria, Cancer and Viruses)
The present review summarizes publications on the artemisinin peroxide fragment synthesis from 1983 to 2016. The data are classified according to the structures of a precursor used in the key peroxidation step of artemisinin peroxide cycle synthesis. The first part of the review comprises the construction of artemisinin peroxide fragment in total syntheses, in which peroxide artemisinin ring resulted from reactions of unsaturated keto derivatives with singlet oxygen or ozone. In the second part, the methods of artemisinin synthesis based on transformations of dihydroartemisinic acid are highlighted. View Full-Text
Keywords: artemisinin; artemisinic acid; organic peroxide; peroxidation; cycles artemisinin; artemisinic acid; organic peroxide; peroxidation; cycles
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MDPI and ACS Style

Vil’, V.A.; Yaremenko, I.A.; Ilovaisky, A.I.; Terent’ev, A.O. Synthetic Strategies for Peroxide Ring Construction in Artemisinin. Molecules 2017, 22, 117.

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