Next Article in Journal
Adsorption of Emerging Ionizable Contaminants on Carbon Nanotubes: Advancements and Challenges
Next Article in Special Issue
Extraction, Purification and Primary Characterization of Polysaccharides from Defatted Peanut (Arachis hypogaea) Cakes
Previous Article in Journal
Synthesis and in Vitro Antiproliferative Evaluation of C-13 Epimers of Triazolyl-d-Secoestrone Alcohols: The First Potent 13α-d-Secoestrone Derivative
Article

In Vivo Anti-Cancer Mechanism of Low-Molecular-Weight Fucosylated Chondroitin Sulfate (LFCS) from Sea Cucumber Cucumaria frondosa

by 1,2, 1,2, 1,2, 1,2, 1,2, 1,2, 1,2, 1,2, 1,2 and 1,2,*
1
Key Laboratory of Marine Drugs, Ministry of Education, School of Medicine and Pharmacy, Ocean University of China, Qingdao 266003, China
2
Shandong Provincial Key Laboratory of Glycoscience and Glycoengineering, Ocean University of China, Qingdao 266003, China
*
Author to whom correspondence should be addressed.
Academic Editors: Quan-Bin Han, Sunan Wang and Shaoping Nie
Molecules 2016, 21(5), 625; https://doi.org/10.3390/molecules21050625
Received: 19 April 2016 / Revised: 6 May 2016 / Accepted: 9 May 2016 / Published: 12 May 2016
(This article belongs to the Special Issue Natural Polysaccharides)
The low-molecular-weight fucosylated chondroitin sulfate (LFCS) was prepared from native fucosylated chondroitin sulfate (FCS), which was extracted and isolated from sea cucumber Cucumaria frondosa, and the anti-cancer mechanism of LFCS on mouse Lewis lung carcinoma (LLC) was investigated. The results showed that LFCS remarkably inhibited LLC growth and metastasis in a dose-dependent manner. LFCS induced cell cycle arrest by increasing p53/p21 expression and apoptosis through activation of caspase-3 activity in LLC cells. Meanwhile, LFCS suppressed the expression of vascular endothelial growth factor (VEGF), increased the expression of tissue inhibitor of metalloproteinase-1 (TIMP-1) and downregulated the matrix metalloproteinases (MMPs) level. Furthermore, LFCS significantly suppressed the activation of ERK1/2/p38 MAPK/NF-κB pathway, which played a prime role in expression of MMPs. All of these data indicate LFCS may be used as anti-cancer drug candidates and deserve further study. View Full-Text
Keywords: low-molecular-weight fucosylated chondroitin sulfate; anti-metastasis; anti-angiogenesis; Lewis lung carcinoma; mechanism; NF-κB low-molecular-weight fucosylated chondroitin sulfate; anti-metastasis; anti-angiogenesis; Lewis lung carcinoma; mechanism; NF-κB
Show Figures

Figure 1

MDPI and ACS Style

Liu, X.; Liu, Y.; Hao, J.; Zhao, X.; Lang, Y.; Fan, F.; Cai, C.; Li, G.; Zhang, L.; Yu, G. In Vivo Anti-Cancer Mechanism of Low-Molecular-Weight Fucosylated Chondroitin Sulfate (LFCS) from Sea Cucumber Cucumaria frondosa. Molecules 2016, 21, 625. https://doi.org/10.3390/molecules21050625

AMA Style

Liu X, Liu Y, Hao J, Zhao X, Lang Y, Fan F, Cai C, Li G, Zhang L, Yu G. In Vivo Anti-Cancer Mechanism of Low-Molecular-Weight Fucosylated Chondroitin Sulfate (LFCS) from Sea Cucumber Cucumaria frondosa. Molecules. 2016; 21(5):625. https://doi.org/10.3390/molecules21050625

Chicago/Turabian Style

Liu, Xiaoxiao, Yong Liu, Jiejie Hao, Xiaoliang Zhao, Yinzhi Lang, Fei Fan, Chao Cai, Guoyun Li, Lijuan Zhang, and Guangli Yu. 2016. "In Vivo Anti-Cancer Mechanism of Low-Molecular-Weight Fucosylated Chondroitin Sulfate (LFCS) from Sea Cucumber Cucumaria frondosa" Molecules 21, no. 5: 625. https://doi.org/10.3390/molecules21050625

Find Other Styles
Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Article Access Map by Country/Region

1
Back to TopTop