Next Article in Journal
Fluidized Bed Membrane Reactors for Ultra Pure H2 Production—A Step forward towards Commercialization
Previous Article in Journal
Effects of Astaxanthin from Litopenaeus Vannamei on Carrageenan-Induced Edema and Pain Behavior in Mice
Article

A New Megastigmane Sesquiterpenoid from Zanthoxylum Schinifolium Sieb. et Zucc

1
Union Hospital Affiliated to Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022, Hubei, China
2
Hubei Key Laboratory of Natural Medicinal Chemistry and Resource Evaluation, School of Pharmacy, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, Hubei, China
3
Tongji Hospital Affiliated to Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, Hubei, China
*
Authors to whom correspondence should be addressed.
Academic Editor: Derek J. McPhee
Molecules 2016, 21(3), 383; https://doi.org/10.3390/molecules21030383
Received: 17 February 2016 / Revised: 15 March 2016 / Accepted: 16 March 2016 / Published: 19 March 2016
(This article belongs to the Section Natural Products Chemistry)
Zanthoxylum schinifolium Sieb. et Zucc. (Rutaceae), a dioecious shrub with hooked prickly branches, has been used as folk medicine for the treatment of the common cold, stomach ache, diarrhea, and jaundice in China, Korea, and Japan. In our phytochemical investigations on this genus, a new megastigmane sesquiterpenoid, which is referred to as schinifolenol A (1), was isolated from Z. schinifolium. The stereochemistry was characterized via the analyses of extensive spectra. The absolute configuration was established by the application of a modified Mosher’s experiment and assisted by a time-dependent density functional theory (TD-DFT) on calculated electronic circular dichroism (ECD). Bioactivity screenings showed that compound 1 exhibited a safe hypotoxicity and a better selectivity on anti-Kaposi’s sarcoma associated herpes virus (KSHV). View Full-Text
Keywords: zanthoxylum schinifolium; megastigmane; sesquiterpenoid; Kaposi’s sarcoma associated herpes virus zanthoxylum schinifolium; megastigmane; sesquiterpenoid; Kaposi’s sarcoma associated herpes virus
Show Figures

Graphical abstract

MDPI and ACS Style

Hu, L.; Wang, K.; Wang, Z.; Liu, J.; Wang, K.; Zhang, J.; Luo, Z.; Xue, Y.; Zhang, Y.; Zhang, Y. A New Megastigmane Sesquiterpenoid from Zanthoxylum Schinifolium Sieb. et Zucc. Molecules 2016, 21, 383. https://doi.org/10.3390/molecules21030383

AMA Style

Hu L, Wang K, Wang Z, Liu J, Wang K, Zhang J, Luo Z, Xue Y, Zhang Y, Zhang Y. A New Megastigmane Sesquiterpenoid from Zanthoxylum Schinifolium Sieb. et Zucc. Molecules. 2016; 21(3):383. https://doi.org/10.3390/molecules21030383

Chicago/Turabian Style

Hu, Linzhen, Kongchao Wang, Zhenzhen Wang, Junjun Liu, Kaiping Wang, Jinwen Zhang, Zengwei Luo, Yongbo Xue, Yu Zhang, and Yonghui Zhang. 2016. "A New Megastigmane Sesquiterpenoid from Zanthoxylum Schinifolium Sieb. et Zucc" Molecules 21, no. 3: 383. https://doi.org/10.3390/molecules21030383

Find Other Styles
Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Article Access Map by Country/Region

1
Back to TopTop