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Molecules 2016, 21(3), 378;

Functionalization of Calcium Sulfate/Bioglass Scaffolds with Zinc Oxide Whisker

State Key Laboratory of High Performance Complex Manufacturing, Central South University, Changsha 410083, China
Shenzhen Research Institute, Central South University, Shenzhen 518057, China
School of Basic Medical Science, Central South University, Changsha 410078, China
Author to whom correspondence should be addressed.
Academic Editor: Derek J. McPhee
Received: 3 February 2016 / Revised: 4 March 2016 / Accepted: 14 March 2016 / Published: 18 March 2016
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There are urgent demands for satisfactory antibacterial activity and mechanical properties of bone scaffolds. In this study, zinc oxide whisker (ZnOw) was introduced into calcium sulfate/bioglass scaffolds. Antimicrobial behavior was analyzed using Escherichia coli (E. coli) and Staphylococcus aureus (S. aureus). The results showed that the scaffolds presented a strong antibacterial activity after introducing ZnOw, due to the antibacterial factors released from the degradation of ZnO. Moreover, ZnOw was also found to have a distinct reinforcing effect on mechanical properties. This was ascribed to whisker pull-out, crack bridging, crack deflection, crack branching and other toughening mechanisms. In addition, the cell culture experiments showed that the scaffolds with ZnOw had a good biocompatibility. View Full-Text
Keywords: zinc oxide whisker; antibacterial activity; mechanical property; biocompatibility; scaffolds zinc oxide whisker; antibacterial activity; mechanical property; biocompatibility; scaffolds

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Shuai, C.; Zhou, J.; Gao, D.; Gao, C.; Feng, P.; Peng, S. Functionalization of Calcium Sulfate/Bioglass Scaffolds with Zinc Oxide Whisker. Molecules 2016, 21, 378.

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