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Molecules 2016, 21(3), 248;

Exotic Vegetable Oils for Cosmetic O/W Nanoemulsions: In Vivo Evaluation

Department of Pharmaceutical Sciences, Faculty of Pharmaceutical Sciences of Ribeirão Preto, University of São Paulo, Avenida do Café, s/n, Bairro Monte Alegre, Ribeirão Preto, SP 14040-903, Brazil
Pharmacy Course Coordination, Centro Universitário Barão de Mauá, R. Ramos de Azevedo, 423, Jardim Paulista, Ribeirão Preto, SP 14090-180, Brazil
College of Pharmacy, Federal University of Rio Grande do Norte, Rua Gustavo Cordeiro de Farias, s/n, Petrópolis, Natal 59012-570, RN, Brazil
Author to whom correspondence should be addressed.
Academic Editor: Alexandru Mihai Grumezescu
Received: 11 November 2015 / Revised: 13 January 2016 / Accepted: 5 February 2016 / Published: 24 February 2016
(This article belongs to the Special Issue Pharmaceutical Nanotechnology: Novel Approaches)
Full-Text   |   PDF [2481 KB, uploaded 24 February 2016]   |  


Oil-in-water nanoemulsions are stable systems with droplet sizes in the 20–200 nm range. The physicochemical properties of these systems may be influenced by the addition of additives. Thus, the influence of ethoxylated (EL) and acetylated lanolin (AL) addition on the droplet size, pH values, electrical conductivity and stability of nanoemulsions was investigated. Then, effect of nano-emulsions additives with EL (NE-EL) or AL (NE-AL) in hydration, oiliness and pH of the skin were evaluated. Nanoemulsion safety was evaluated through the observation of no undesirable effects after skin formulation application. Both additives caused changes in droplet size and electrical conductivity, but not in pH values. Nanoemulsions containing up to 6.0% ethoxylated lanolin and 2.0% acetylated lanolin remained stable after centrifugation tests. Higher concentrations of the additives made the nanoemulsions unstable. Stability tests showed that ethoxylated lanolin produced more stable nanoemulsions then acetylated lanolin and that the major instability phenomenon occurring in these systems is coalescence at elevated temperatures. Nanoemulsion-based lanolin derivatives increased skin hydration and oiliness and did not change cutaneous pH values. These formulations are non-toxic since they did not cause any irritation on the skin surface after nanoemulsion application, showing potential as carriers for pharmaceuticals and cosmetic applications. View Full-Text
Keywords: nanoemulsions; raspberry seed oil; passion fruit oil; peach oil; lanolin; skin hydration nanoemulsions; raspberry seed oil; passion fruit oil; peach oil; lanolin; skin hydration

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Pereira, T.A.; Guerreiro, C.M.; Maruno, M.; Ferrari, M.; Rocha-Filho, P.A. Exotic Vegetable Oils for Cosmetic O/W Nanoemulsions: In Vivo Evaluation. Molecules 2016, 21, 248.

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