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Molecules 2016, 21(2), 195;

The Anti-Atherosclerotic Effect of Naringin Is Associated with Reduced Expressions of Cell Adhesion Molecules and Chemokines through NF-κB Pathway

Department of Chinese Medicine and Mitochondrial Research Unit, Kaohsiung Chang Gung Memorial Hospital and Chang Gung University College of Medicine, No. 123, Da-Pei Road, Niao-Sung District, Kaohsiung 83301, Taiwan
Graduate Institute of Clinical Medical Sciences, Chang Gung University, No. 259, Wen-Hua 1st Road, Kwei-Shan, Tao-Yuan 33302, Taiwan
Division of General Surgery, Ministry of Health and Welfare Pingtung Hospital, No. 270, Ziyou Road, Pingtung City, Pingtung County 900, Taiwan
School of Chinese Medicine, China Medical University, No. 91, Hsueh-Shih Road, Taichung 40402, Taiwan
These authors contributed equally to this work.
Author to whom correspondence should be addressed.
Academic Editor: Isabel C. F. R. Ferreira
Received: 16 January 2016 / Accepted: 26 January 2016 / Published: 5 February 2016
(This article belongs to the Section Natural Products Chemistry)
Full-Text   |   PDF [3465 KB, uploaded 5 February 2016]   |  


Naringin has been reported to have an anti-atherosclerosis effect but the underlying mechanism is not fully understood. The aim of this study is to investigate the impact of naringin on the TNF-α-induced expressions of cell adhesion molecules, chemokines and NF-κB signaling pathway in human umbilical vein endothelial cells (HUVECs). The experiments revealed that naringin, at concentrations without cytotoxicity, dose-dependently inhibited the adhesion of THP-1 monocytes to the TNF-α-stimulated HUVECs. The TNF-α-induced expressions of cell adhesion molecules, including VCAM-1, ICAM-1 and E-selectin, at both the mRNA and protein levels, were significantly suppressed by naringin in a dose dependent manner. In addition, the TNF-α-induced mRNA and protein levels of chemokines, including fractalkine/CX3CL1, MCP-1 and RANTES, were also reduced by naringin. Naringin significantly inhibited TNF-α-induced nuclear translocation of NF-κB, which resulted from the inhibited phosphorylation of IKKα/β, IκB-α and NF-κB. Altogether, we proposed that naringin modulated TNF-α-induced expressions of cell adhesion molecules and chemokines through the inhibition of TNF-α-induced activation of IKK/NF-κB signaling pathway to exert the anti-atherosclerotic effect. View Full-Text
Keywords: naringin; atherosclerosis; TNF-α; chemokines; NF-κB naringin; atherosclerosis; TNF-α; chemokines; NF-κB

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Hsueh, T.-P.; Sheen, J.-M.; Pang, J.-H.S.; Bi, K.-W.; Huang, C.-C.; Wu, H.-T.; Huang, S.-T. The Anti-Atherosclerotic Effect of Naringin Is Associated with Reduced Expressions of Cell Adhesion Molecules and Chemokines through NF-κB Pathway. Molecules 2016, 21, 195.

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