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Molecules 2016, 21(11), 1506;

Anti-Complementary Components of Helicteres angustifolia

State Key Laboratory of Natural Medicines, China Pharmaceutical University, Nanjing 210009, China
Department of Pharmacognosy, School of Pharmacy, Fudan University, Shanghai 201203, China
Author to whom correspondence should be addressed.
Academic Editor: Derek J. McPhee
Received: 11 October 2016 / Revised: 5 November 2016 / Accepted: 6 November 2016 / Published: 10 November 2016
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A first phenalenon derivative with an acetyl side chain at C-8, 8-acetyl-9-hydroxy-3-methoxy-7-methyl-1-phenalenon (compound 1), and a pair of new sesquilignan epimers at C-7″ of hedyotol C and hedyotol D analogs, hedyotol C 7″-O-β-d-glucopyranoside (compound 2) and hedyotol D 7″-O-β-d-glucopyranoside (compound 3) were isolated from the aerial parts of Helicteres angustifolia together with nine known compounds (412). Their structures were elucidated on the basis of spectroscopic methods, including mass spectroscopy, and 1D and 2D nuclear magnetic resonance. Eleven isolates exhibited anti-complementary activity. In particular, compounds 4 and 5 exhibited potent anti-complementary activities against the classical and alternative pathways with CH50 values of 0.040 ± 0.009 and 0.009 ± 0.002 mM, and AP50 values of 0.105 ± 0.015 and 0.021 ± 0.003 mM, respectively. The targets of compounds 4 and 5 in the complement activation cascade were also identified. In conclusion, the anti-complementary components of H. angustifolia possessed chemical diversity and consisted mostly of flavonoids and lignans in this study. View Full-Text
Keywords: Helicteres angustifolia; sterculiaceae; phenalenone; sesquilignan; anti-complement Helicteres angustifolia; sterculiaceae; phenalenone; sesquilignan; anti-complement

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Yin, X.; Lu, Y.; Cheng, Z.-H.; Chen, D.-F. Anti-Complementary Components of Helicteres angustifolia. Molecules 2016, 21, 1506.

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