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Molecules 2016, 21(10), 1268;

Palladium-Catalyzed C–H Arylation of 1,2,3-Triazoles

Department of Biochemistry, UT Southwestern Medical Center, Dallas, TX 75390, USA
Author to whom correspondence should be addressed.
Academic Editor: Georgiy B. Shul’pin
Received: 5 August 2016 / Revised: 15 September 2016 / Accepted: 16 September 2016 / Published: 22 September 2016
(This article belongs to the Special Issue Reactions of Hydrocarbons and other C‒H Compounds)
Full-Text   |   PDF [457 KB, uploaded 22 September 2016]


Palladium(II) acetate, in combination with triphenylphosphine, catalyzes direct arylation of 1,4-disubstituted 1,2,3-triazoles effectively. This C–H arylation reaction provides facile access to fully substituted triazoles with well-defined regiochemistry. View Full-Text
Keywords: C–H arylation; palladium; triazole C–H arylation; palladium; triazole
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited (CC BY 4.0).

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Zhang, C.; You, L.; Chen, C. Palladium-Catalyzed C–H Arylation of 1,2,3-Triazoles. Molecules 2016, 21, 1268.

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