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Molecules 2015, 20(9), 16235-16254;

The Biosynthetic Pathways of Tanshinones and Phenolic Acids in Salvia miltiorrhiza

Pharmacy College, Chengdu University of Traditional Chinese Medicine, Chengdu 611137, China
State Key Laboratory Breeding Base of Dao-Di Herbs, National Resource Center for Chinese Materia Medica, China Academy of Chinese Medical Sciences, Beijing 100700, China
Beijing Key Laboratory of Protection and Application of Chinese Medicinal Resources, Beijing Normal University, Beijing 100875, China
Pharmaceutical College, Guiyang College of Traditional Chinese Medicine, Guiyang 550002, China
These authors contributed equally to this work.
Authors to whom correspondence should be addressed.
Academic Editor: Derek J. McPhee
Received: 19 July 2015 / Accepted: 24 August 2015 / Published: 8 September 2015
(This article belongs to the Section Metabolites)
Full-Text   |   PDF [2149 KB, uploaded 8 September 2015]   |  


Secondary metabolites from plants play key roles in human medicine and chemical industries. Due to limited accumulation of secondary metabolites in plants and their important roles, characterization of key enzymes involved in biosynthetic pathway will enable metabolic engineering or synthetic biology to improve or produce the compounds in plants or microorganisms, which provides an alternative for production of these valuable compounds. Salvia miltiorrhiza, containing tanshinones and phenolic acids as its active compounds, has been widely used for the treatment of cardiovascular and cerebrovascular diseases. The biosynthetic analysis of secondary metabolites in S. miltiorrhiza has made great progress due to the successful genetic transformation system, simplified hairy roots system, and high-throughput sequencing. The cloned genes in S. miltiorrhiza had provided references for functional characterization of the post-modification steps involved in biosynthesis of tanshinones and phenolic acids, and further utilization of these steps in metabolic engineering. The strategies used in these studies could provide solid foundation for elucidation of biosynthetic pathways of diterpenoids and phenolic acids in other species. The present review systematically summarizes recent advances in biosynthetic pathway analysis of tanshinones and phenolic acids as well as synthetic biology and metabolic engineering applications of the rate-limiting genes involved in the secondary metabolism in S. miltiorrhiza. View Full-Text
Keywords: tanshinones; phenolic acids; Salvia miltiorrhiza; biosynthetic pathway; metabolic engineering tanshinones; phenolic acids; Salvia miltiorrhiza; biosynthetic pathway; metabolic engineering

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Ma, X.-H.; Ma, Y.; Tang, J.-F.; He, Y.-L.; Liu, Y.-C.; Ma, X.-J.; Shen, Y.; Cui, G.-H.; Lin, H.-X.; Rong, Q.-X.; Guo, J.; Huang, L.-Q. The Biosynthetic Pathways of Tanshinones and Phenolic Acids in Salvia miltiorrhiza. Molecules 2015, 20, 16235-16254.

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