Next Article in Journal
Reactivity of Amine/E(C6F5)3 (E = B, Al) Lewis Pairs toward Linear and Cyclic Acrylic Monomers: Hydrogenation vs. Polymerization
Previous Article in Journal
Practical Radiosynthesis and Preclinical Neuroimaging of [11C]isradipine, a Calcium Channel Antagonist
Article

Comparative Studies on Polyphenolic Composition, Antioxidant and Diuretic Effects of Nigella sativa L. (Black Cumin) and Nigella damascena L. (Lady-in-a-Mist) Seeds

1
Faculty of Medicine, Pharmacy and Dental Medicine, Vasile Goldiș Western University of Arad, 86, Rebreanu Street, Arad 310414, Romania
2
SC PlantExtrakt SRL, Rădaia 407059, Cluj, Romania
3
Faculty of Pharmacy, Iuliu Hațieganu University of Medicine and Pharmacy, 8, V. Babes Street, Cluj-Napoca 400010, Romania
*
Authors to whom correspondence should be addressed.
Academic Editor: Derek J. McPhee
Molecules 2015, 20(6), 9560-9574; https://doi.org/10.3390/molecules20069560
Received: 20 April 2015 / Revised: 17 May 2015 / Accepted: 18 May 2015 / Published: 26 May 2015
(This article belongs to the Section Natural Products Chemistry)
This study was performed to evaluate the phenolic profile, antioxidant and diuretic effects of black cumin and lady-in-a-mist seeds. In the phenolic profile, differences between the two species are significant. Qualitative and quantitative analyses of the phenolic compounds were performed using a HPLC-UV/MS method. Hyperoside was the only identified flavonoid glycoside (1.08 ± 0.01 μg∙g−1 dw plant material), in the N. damascena extract. Regarding the flavonol profile, kaempferol was identified before the hydrolysis, only in the N. sativa extract (6.06 ± 0.02 μg∙g−1 dw plant material) and quercetin only in N. damascena seeds (14.35 ± 0.02 μg∙g−1 dw plant material). The antioxidant potential of the two species was tested through several electron transfer assays, which indicated, excepting for the FRAP assay, N. damascena as exhibiting a higher free radical scavenging activity. The diuretic activity of the two extracts was tested using a rat-experimental model on acute diuresis. Administration of the ethanolic extract of N. sativa (100 mg∙kg−1) resulted in a significant increase in urine volume, although less than found with the reference drug; in addition N. damascena extract did not present a diuretic effect. In reference to the elimination of Na+, K+ and uric acid, the black cumin extract exhibited a higher natriuretic than kaluretic effect and a similar uricosuric effect with control and N. damascena. For N. damascena, the Na+/K+ ratio was sub unitary, but not due to an increasing of the kaluretic effect, but mostly to a decrease of Na+ excretion. View Full-Text
Keywords: Nigella sativa L.; N. damascena L.; polyphenols; antioxidants; diuretic; seeds Nigella sativa L.; N. damascena L.; polyphenols; antioxidants; diuretic; seeds
MDPI and ACS Style

Toma, C.-C.; Olah, N.-K.; Vlase, L.; Mogoșan, C.; Mocan, A. Comparative Studies on Polyphenolic Composition, Antioxidant and Diuretic Effects of Nigella sativa L. (Black Cumin) and Nigella damascena L. (Lady-in-a-Mist) Seeds. Molecules 2015, 20, 9560-9574. https://doi.org/10.3390/molecules20069560

AMA Style

Toma C-C, Olah N-K, Vlase L, Mogoșan C, Mocan A. Comparative Studies on Polyphenolic Composition, Antioxidant and Diuretic Effects of Nigella sativa L. (Black Cumin) and Nigella damascena L. (Lady-in-a-Mist) Seeds. Molecules. 2015; 20(6):9560-9574. https://doi.org/10.3390/molecules20069560

Chicago/Turabian Style

Toma, Claudia-Crina, Neli-Kinga Olah, Laurian Vlase, Cristina Mogoșan, and Andrei Mocan. 2015. "Comparative Studies on Polyphenolic Composition, Antioxidant and Diuretic Effects of Nigella sativa L. (Black Cumin) and Nigella damascena L. (Lady-in-a-Mist) Seeds" Molecules 20, no. 6: 9560-9574. https://doi.org/10.3390/molecules20069560

Find Other Styles

Article Access Map by Country/Region

1
Only visits after 24 November 2015 are recorded.
Back to TopTop