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Open AccessArticle

Nanocapsular Dispersion of Cinnamaldehyde for Enhanced Inhibitory Activity against Aflatoxin Production by Aspergillus flavus

by Hongbo Li 1,2,†, Qingshan Shen 2,†, Wei Zhou 2, Haizhen Mo 2, Daodong Pan 1,* and Liangbin Hu 2,*
1
School of Marine Science, Ningbo University, Ningbo 315211, China
2
Department of Food Science, Henan Institute of Science and Technology, Xinxiang 453003, China
*
Authors to whom correspondence should be addressed.
These authors contributed equally to this work.
Academic Editor: Derek J. McPhee
Molecules 2015, 20(4), 6022-6032; https://doi.org/10.3390/molecules20046022
Received: 10 March 2015 / Revised: 31 March 2015 / Accepted: 1 April 2015 / Published: 7 April 2015
(This article belongs to the Section Natural Products Chemistry)
Cinnamaldehyde (CA) is marginally soluble in water, making it challenging to evenly disperse it in foods, and resulting in lowered anti-A. flavus efficacy. In the present study, nano-dispersed CA (nano-CA) was prepared to increase its aqueous solubility. Free and nano-dispersed CA were compared in terms of their inhibitory activity against fungal growth and aflatoxin production of A. flavus both in Sabouraud Dextrose (SD) culture and in peanut butter. Our results indicated that free CA inhibited the mycelia growth and aflatoxin production of A. flavus with a minimal inhibitory concentration (MIC) value of 1.0 mM, but promoted the aflatoxin production at some concentrations lower than the MIC. Nano-CA had a lower MIC value of 0.8 mM against A. flavus, and also showed improved activity against aflatoxin production without the promotion at lower dose. The solidity of peanut butter had an adverse impact on the antifungal activity of free CA, whereas nano-dispersed CA showed more than 2-fold improved activity against the growth of A. flavus. Free CA still promoted AFB1 production at the concentration of 0.25 mM, whereas nano-CA showed more efficient inhibition of AFB1 production in the butter. View Full-Text
Keywords: cinnamaldehyde; nano-dispersion; aflatoxin; inhibition; peanut butter cinnamaldehyde; nano-dispersion; aflatoxin; inhibition; peanut butter
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Li, H.; Shen, Q.; Zhou, W.; Mo, H.; Pan, D.; Hu, L. Nanocapsular Dispersion of Cinnamaldehyde for Enhanced Inhibitory Activity against Aflatoxin Production by Aspergillus flavus. Molecules 2015, 20, 6022-6032.

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