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Molecules 2015, 20(12), 22301-22314;

Potent PPARγ Ligands from Swietenia macrophylla Are Capable of Stimulating Glucose Uptake in Muscle Cells

Experimental Therapeutics Center, Institute of Pharmaceuticals and Nutraceuticals Malaysia, Blok 5-A, Halaman Bukit Gambir, Penang 11700, Malaysia
Biomolecular Research Group, Biochemistry Program, Institute of Biological Sciences, Faculty of Science, University of Malaya, Kuala Lumpur 50603, Malaysia
Biomedical Research Laboratory, Jeffrey Cheah School of Medicine and Health Sciences, Monash University Malaysia, Bandar Sunway 46150, Selangor Darul Ehsan, Malaysia
School of Biological Sciences, Universiti Sains Malaysia, Penang 11800 USM, Malaysia
Institute of Marine Biotechnology, Universiti Malaysia Terengganu, Kuala Terengganu 21030, Terengganu, Malaysia
Author to whom correspondence should be addressed.
Academic Editor: Derek J. McPhee
Received: 22 October 2015 / Revised: 27 November 2015 / Accepted: 1 December 2015 / Published: 12 December 2015
(This article belongs to the Section Natural Products Chemistry)
Full-Text   |   PDF [3982 KB, uploaded 12 December 2015]   |  


Numerous documented ethnopharmacological properties have been associated with Swietenia macrophylla (Meliaceae), with its seed extract reported to display anti-hypoglycemic activities in diabetic rats. In the present study, three compounds isolated from the seeds of S. macrophylla were tested on a modified ELISA binding assay and showed to possess PPARγ ligand activity. They were corresponded to PPARγ-mediated cellular response, stimulated adipocyte differentiation but produced lower amount of fat droplets compared to a conventional anti-diabetic agent, rosiglitazone. The up-regulation of adipocytes was followed by increased adipocyte-related gene expressions such as adiponectin, adipsin, and PPARγ. The S. macrophylla compounds also promoted cellular glucose uptake via the translocation of GLUT4 glucose transporter. View Full-Text
Keywords: Swietenia macrophylla; PPARγ ligand; GLUT4 translocation; glucose uptake Swietenia macrophylla; PPARγ ligand; GLUT4 translocation; glucose uptake

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Lau, W.K.; Goh, B.H.; Kadir, H.A.; Shu-Chien, A.C.; Tengku Muhammad, T.S. Potent PPARγ Ligands from Swietenia macrophylla Are Capable of Stimulating Glucose Uptake in Muscle Cells. Molecules 2015, 20, 22301-22314.

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