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Open AccessArticle

The Restorative Effects of Eucommia ulmoides Oliver Leaf Extract on Vascular Function in Spontaneously Hypertensive Rats

1
R & D Center, Kobayashi Pharmaceutical Co., Ltd., 1-30-3, Toyokawa, Ibaraki, Osaka 657-0057, Japan
2
Department of Bioscience and Biotechnology, Graduate School of Agriculture, Shinshu University, 8304, Minamiminowa, Nagano 399-4598, Japan
3
Department of Pharmaceutical Sciences, Health Sciences University of Hokkaido, 1757 Kanazawa, Tobetsu-cho, Ishikari, Hokkaido 061-0293, Japan
*
Authors to whom correspondence should be addressed.
Academic Editor: Derek J. McPhee
Molecules 2015, 20(12), 21971-21981; https://doi.org/10.3390/molecules201219826
Received: 13 October 2015 / Revised: 24 November 2015 / Accepted: 2 December 2015 / Published: 9 December 2015
(This article belongs to the Section Natural Products Chemistry)
Eucommia ulmoides Oliv. leaf is a traditional Chinese antihypertensive and antidiabetic medicine. We examined the effects of chronic Eucommia leaf extract (ELE) administration on artery function and morphology in spontaneously hypertensive rats (SHRs). ELE was orally administered via normal diet ad libitum to six-week-old male SHRs at a concentration of 5% for seven weeks. Acetylcholine (ACh)-induced endothelium-dependent relaxation, sodium nitroprusside (SNP)-induced endothelium-independent relaxation, plasma nitric oxide (NO) levels, and media thickness were assessed. ELE significantly improved ACh-induced aortic endothelium-dependent relaxation but did not affect SNP-induced endothelium-independent relaxation in the SHRs, as compared to the animals receiving normal diet. Plasma NO levels and media thickness were significantly increased and decreased, respectively, in the ELE-treated SHRs. Therefore, long-term ELE administration may effectively improve vascular function by increasing plasma NO levels and bioavailability, and by preventing vascular hypertrophy in the SHR aorta. View Full-Text
Keywords: Eucommia leaf extract; ACh-induced endothelium-dependent relaxation; nitric oxide; aortic media thickness; spontaneously hypertensive rat Eucommia leaf extract; ACh-induced endothelium-dependent relaxation; nitric oxide; aortic media thickness; spontaneously hypertensive rat
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Hosoo, S.; Koyama, M.; Kato, M.; Hirata, T.; Yamaguchi, Y.; Yamasaki, H.; Wada, A.; Wada, K.; Nishibe, S.; Nakamura, K. The Restorative Effects of Eucommia ulmoides Oliver Leaf Extract on Vascular Function in Spontaneously Hypertensive Rats. Molecules 2015, 20, 21971-21981.

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